TSEN15

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.^[5][6][7]

TSEN15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GW6
Identifiers
Aliases	TSEN15, C1orf19, sen15, tRNA splicing endonuclease subunit 15, PCH2F
External IDs	OMIM: 608756; MGI: 1913887; HomoloGene: 12002; GeneCards: TSEN15; OMA:TSEN15 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 184,051,651 bp[1] End 184,123,978 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G2 Start 152,246,486 bp[2] End 152,262,439 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle cardiac muscle tissue of right atrium C1 segment biceps brachii vastus lateralis muscle Skeletal muscle tissue of biceps brachii corpus epididymis Brodmann area 46 deltoid muscle ventricular zone Top expressed in yolk sac epiblast embryo ventricular zone embryo quadriceps femoris muscle olfactory bulb placenta heart skeletal muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA-intron endonuclease activity nucleic acid binding nuclease activity Cellular component nucleolus nucleus nucleoplasm Biological process mRNA processing RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic tRNA processing tRNA splicing, via endonucleolytic cleavage and ligation nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116461 66637 Ensembl ENSG00000198860 ENSMUSG00000014980 UniProt Q8WW01 Q8R3W5 RefSeq (mRNA) NM_001127394 NM_001300764 NM_001300766 NM_052965 NM_001363643 NM_025677 RefSeq (protein) NP_001120866 NP_001287693 NP_001287695 NP_443197 NP_001350572 NP_079953 Location (UCSC) Chr 1: 184.05 – 184.12 Mb Chr 1: 152.25 – 152.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[7]

Interactions

C1orf19 has been shown to interact with TSEN2.^[8]