TRIT1

tRNA isopentenyltransferase, mitochondrial is an enzyme that in humans is encoded by the TRIT1 gene.

TRIT1
Identifiers
Aliases	TRIT1, IPT, MOD5, GRO1, IPPT, IPTase, hGRO1, tRNA isopentenyltransferase 1, COXPD35
External IDs	OMIM: 617840; MGI: 1914216; HomoloGene: 7010; GeneCards: TRIT1; OMA:TRIT1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 39,838,110 bp[1] End 39,883,511 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 122,910,390 bp[2] End 122,948,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte body of pancreas skin of leg vagina skin of abdomen right uterine tube secondary oocyte left lobe of thyroid gland prostate body of uterus Top expressed in saccule medullary collecting duct otic vesicle renal corpuscle otic placode lacrimal gland hair follicle cumulus cell primary oocyte fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ATP binding metal ion binding tRNA dimethylallyltransferase activity nucleic acid binding zinc ion binding Cellular component cytoplasm mitochondrial matrix mitochondrion cellular component Biological process mitochondrial tRNA modification tRNA processing tRNA modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54802 66966 Ensembl ENSG00000043514 ENSMUSG00000028653 UniProt Q9H3H1 Q80UN9 RefSeq (mRNA) NM_001312691 NM_001312692 NM_017646 NM_025873 RefSeq (protein) NP_001299620 NP_001299621 NP_060116 NP_080149 Location (UCSC) Chr 1: 39.84 – 39.88 Mb Chr 4: 122.91 – 122.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

It catalyzes the addition of an isopentenyl group from dimethylallyl diphosphate (DMAPP) onto adenosine residue 37 of certain tRNA molecules.^[5][6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000043514 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028653 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Golovko A, Hjalm G, Sitbon F, Nicander B (Jan 2001). "Cloning of a human tRNA isopentenyl transferase". Gene. 258 (1–2): 85–93. doi:10.1016/S0378-1119(00)00421-2. PMID 11111046.
6. Spinola M, Galvan A, Pignatiello C, Conti B, Pastorino U, Nicander B, Paroni R, Dragani TA (Aug 2005). "Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer". Oncogene. 24 (35): 5502–9. doi:10.1038/sj.onc.1208687. PMID 15870694.
7. "Entrez Gene: TRIT1 tRNA isopentenyltransferase 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lemieux J, Lakowski B, Webb A, et al. (2002). "Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria". Genetics. 159 (1): 147–57. doi:10.1093/genetics/159.1.147. PMC 1461807. PMID 11560893.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Spinola M, Falvella FS, Galvan A, et al. (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival" (PDF). Lung Cancer. 55 (3): 271–7. doi:10.1016/j.lungcan.2006.10.023. hdl:2434/25016. PMID 17145094.