TRADD

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.^[5][6]

TRADD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F2H, 1F3V
Identifiers
Aliases	TRADD, Hs.89862, TNFRSF1A associated via death domain
External IDs	OMIM: 603500; MGI: 109200; HomoloGene: 2807; GeneCards: TRADD; OMA:TRADD - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,154,185 bp[1] End 67,159,909 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.04 cM Start 105,984,918 bp[2] End 105,991,241 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell granulocyte right uterine tube mucosa of transverse colon amniotic fluid parotid gland blood palpebral conjunctiva epithelium of nasopharynx gingival epithelium Top expressed in intestinal villus left colon Ileal epithelium lumbar spinal ganglion jejunum plantaris muscle extensor digitorum longus muscle duodenum blood epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function death domain binding kinase binding protein binding identical protein binding tumor necrosis factor receptor binding protein-containing complex binding molecular adaptor activity transmembrane receptor protein tyrosine kinase adaptor activity Cellular component cytoplasm cytosol receptor complex plasma membrane death-inducing signaling complex membrane raft cytoskeleton nucleus protein-containing complex Biological process extrinsic apoptotic signaling pathway positive regulation of hair follicle development regulation of tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway death-inducing signaling complex assembly positive regulation of NF-kappaB transcription factor activity positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of extrinsic apoptotic signaling pathway via death domain receptors I-kappaB kinase/NF-kappaB signaling activation of cysteine-type endopeptidase activity involved in apoptotic process extrinsic apoptotic signaling pathway via death domain receptors signal transduction apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors protein heterooligomerization positive regulation of cell migration positive regulation of inflammatory response cellular response to tumor necrosis factor positive regulation of NIK/NF-kappaB signaling transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8717 71609 Ensembl ENSG00000102871 ENSMUSG00000031887 UniProt Q15628 Q3U0V2 RefSeq (mRNA) NM_003789 NM_153425 NM_001323552 NM_001033161 RefSeq (protein) NP_001310481 NP_003780 NP_001028333 Location (UCSC) Chr 16: 67.15 – 67.16 Mb Chr 8: 105.98 – 105.99 Mb PubMed search [3] [4]
Wikidata
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TRADD is an adaptor protein.

Function

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-κB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.^[6]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

Interactions

TRADD has been shown to interact with:

• FADD,^[7][8][9]
• Keratin 18^[10]
• RIPK1,^[11]
• STAT1,^[12]
• TNFRSF1A,^{[7][11][13][14][15][16][17]}
• TNFRSF25,^[18] and
• TRAF2.^{[7][19][20][21][22][23][24]}

See also

• TRAF
• RIP