TNFRSF19

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.^[5]

TNFRSF19
Identifiers
Aliases	TNFRSF19, TAJ, TAJ-alpha, TRADE, TROY, tumor necrosis factor receptor superfamily member 19, TNF receptor superfamily member 19
External IDs	OMIM: 606122; MGI: 1352474; HomoloGene: 8481; GeneCards: TNFRSF19; OMA:TNFRSF19 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.12 Start 23,570,370 bp[1] End 23,676,104 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 61,201,324 bp[2] End 61,283,939 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of thigh bronchial epithelial cell skin of hip mucosa of paranasal sinus skin of abdomen ventricular zone right uterine tube trachea olfactory zone of nasal mucosa Top expressed in bronchus calvaria molar main bronchus body of femur epithelium of bronchus maxillary prominence skin of external ear upper jaw vestibular sensory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function tumor necrosis factor-activated receptor activity signaling receptor activity protein binding Cellular component integral component of membrane membrane intracellular anatomical structure plasma membrane Biological process hair follicle development JNK cascade apoptotic process positive regulation of JNK cascade tissue development positive regulation of I-kappaB kinase/NF-kappaB signaling tumor necrosis factor-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55504 29820 Ensembl ENSG00000127863 ENSMUSG00000060548 UniProt Q9NS68 Q9JLL3 RefSeq (mRNA) NM_001204458 NM_001204459 NM_018647 NM_148957 NM_001354985 NM_001164155 NM_013869 RefSeq (protein) NP_001191387 NP_001191388 NP_061117 NP_683760 NP_001341914 NP_001157627 NP_038897 Location (UCSC) Chr 13: 23.57 – 23.68 Mb Chr 14: 61.2 – 61.28 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[5]

See also

• Mitogen-activated protein kinase for JNK signaling pathway description