THCP-O-acetate

THCP-O-acetate (THCP-O) is a semi-synthetic derivative of tetrahydrocannabiphorol (THCP) derived by acetylation of the OH group. It has been found as a component of grey-market cannabis products such as e-cigarette liquids and edible gummy lollies, and is allegedly a potent and long-lasting psychoactive cannabinoid.^[1]

THCP-O-acetate

Identifiers
IUPAC name (6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-yl acetate
CAS Number	2829292-82-0
ChemSpider	129341098
Chemical and physical data
Formula	C25H36O3
Molar mass	384.560 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=O)Oc1cc(CCCCCCC)cc2OC(C)(C)[C@@H]3CCC(C)=C[C@H]3c21
InChI InChI=1S/C25H36O3/c1-6-7-8-9-10-11-19-15-22(27-18(3)26)24-20-14-17(2)12-13-21(20)25(4,5)28-23(24)16-19/h14-16,20-21H,6-13H2,1-5H3/t20-,21-/m1/s1 Key:OXMUZNKOOOITQD-NHCUHLMSSA-N

Toxicity

In 2022, researchers at Portland State University who screened for the presence of reacted ketene as N-benzylacetamide reported that Vitamin E acetate, CBD-acetate, CBN-acetate and THC-O-acetate may break down to release ketene gas when heated at 340 °C (644 °F).^[2][3]

Legality

Japan banned THCP-O-Acetate along with HHCP on December 26, 2023.^[4]

See also

• Tetrahydrocannabiphorol
• Hexahydrocannabiphorol (HHCP)
• HHCP-O-acetate
• THC-O-acetate
• Dimethylheptylpyran (DMHP)
• HU-210
• THC-O-phosphate
• THC hemisuccinate
• THC morpholinylbutyrate