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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.[5]
TECR | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TECR, GPSN2, MRT14, SC2, TER, trans-2,3-enoyl-CoA reductase | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 610057; MGI: 1915408; HomoloGene: 36231; GeneCards: TECR; OMA:TECR - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[5]
Mutations in this gene have been shown to cause non-syndromic mental retardation.[6]
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