TAX1BP1

Tax1-binding protein 1 is a protein that in humans is encoded by the TAX1BP1 gene.^[5]

TAX1BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M7Q, 4BMJ, 4NLH, 5AAS, 4Z4M, 4Z4K
Identifiers
Aliases	TAX1BP1, CALCOCO3, T6BP, TXBP151, Tax1 binding protein 1
External IDs	OMIM: 605326; MGI: 1289308; HomoloGene: 4395; GeneCards: TAX1BP1; OMA:TAX1BP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 27,739,331 bp[1] End 27,844,564 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.7 cM Start 52,690,714 bp[2] End 52,743,765 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte bronchial epithelial cell retinal pigment epithelium amniotic fluid epithelium of nasopharynx oral cavity Epithelium of choroid plexus mucosa of paranasal sinus nasal epithelium right ventricle Top expressed in Ileal epithelium corneal stroma olfactory epithelium left colon spermatid lactiferous gland tail of embryo choroid plexus of fourth ventricle zygote seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase binding protein binding metal ion binding Cellular component cytosol extracellular exosome Biological process regulation of tumor necrosis factor-mediated signaling pathway negative regulation of type I interferon production negative regulation of apoptotic process negative regulation of NF-kappaB transcription factor activity apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8887 52440 Ensembl ENSG00000106052 ENSMUSG00000004535 UniProt Q86VP1 Q3UKC1 RefSeq (mRNA) NM_001079864 NM_001206901 NM_001206902 NM_006024 NM_001362794 NM_001362795 NM_025816 NM_001355595 NM_001355596 RefSeq (protein) NP_001073333 NP_001193830 NP_001193831 NP_006015 NP_001349723 NP_001349724 NP_080092 NP_001342524 NP_001342525 Location (UCSC) Chr 7: 27.74 – 27.84 Mb Chr 6: 52.69 – 52.74 Mb PubMed search [3] [4]
Wikidata
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Interactions

TAX1BP1 has been shown to interact with TNFAIP3^[6] and TRAF6.^[7] TAX1BP1 binds to TNFAIP3 or TRAF6 and suppresses NF-kappaB transcriptional activation.