TASP1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

TASP1

Threonine aspartase 1 is an enzyme that in humans is encoded by the TASP1 gene.[5][6]

Quick Facts Available structures, PDB ...
TASP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTASP1, C20orf13, dJ585I14.2, taspase 1, SULEHS
External IDsOMIM: 608270; MGI: 1923062; HomoloGene: 9795; GeneCards: TASP1; OMA:TASP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017714
NM_001323602
NM_001323603
NM_001323604

NM_001159640
NM_001159641
NM_001289611
NM_175225

RefSeq (protein)

NP_001310531
NP_001310532
NP_001310533
NP_060184

NP_001153112
NP_001153113
NP_001276540
NP_780434

Location (UCSC)Chr 20: 13.39 – 13.64 MbChr 2: 139.68 – 139.91 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Cleavage of TFIIA has been found to drive spermatogenesis.[7]

Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

Clinical significance

Taspase1 is overexpressed in primary human cancers and functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. Therefore, Taspase1 may serve as a novel anti-cancer therapeutic target.[8]

References

Further reading

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