TARS (gene)

Threonyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the TARS gene.^[5]

TARS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WWT, 4HWT, 4P3N, 4TTV
Identifiers
Aliases	TARS1, ThrRS, threonyl-tRNA synthetase, TARS, threonyl-tRNA synthetase 1, TTD7
External IDs	OMIM: 187790; MGI: 106314; HomoloGene: 11852; GeneCards: TARS1; OMA:TARS1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.3 Start 33,440,696 bp[1] End 33,468,091 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 5.6 cM Start 11,382,387 bp[2] End 11,399,751 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve islet of Langerhans mucosa of transverse colon gums gingival epithelium ventricular zone buccal mucosa cell epithelium of colon oral cavity cartilage tissue Top expressed in primitive streak epiblast endothelial cell of lymphatic vessel seminal vesicula calvaria hair follicle left lobe of liver genital tubercle tail of embryo lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity protein binding ATP binding protein homodimerization activity threonine-tRNA ligase activity tRNA binding RNA binding Cellular component extracellular exosome actin cytoskeleton cytoplasm cytosol Biological process tRNA aminoacylation tRNA aminoacylation for protein translation protein biosynthesis threonyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6897 110960 Ensembl ENSG00000113407 ENSMUSG00000022241 UniProt P26639 Q9D0R2 RefSeq (mRNA) NM_001258437 NM_001258438 NM_152295 NM_033074 RefSeq (protein) NP_001245366 NP_001245367 NP_689508 NP_149065 Location (UCSC) Chr 5: 33.44 – 33.47 Mb Chr 15: 11.38 – 11.4 Mb PubMed search [3] [4]
Wikidata
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Aminoacyl tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family^[5]

See also

• Aminoacyl tRNA synthetase