T98G

T98G is a glioblastoma cell line used in brain cancer research and drug development.^[1][2]

The ACTA2 protein, which is involved in muscle contraction, is present in large amounts in the T98G cell line.

The T98G cell line was derived from a 61-year-old human male and has a hyper pentaploid chromosome count with a modal number ranging from 128 to 132. The cells are not tumorigenic in mice but do proliferate with proper anchorage in cell culture.^[1] T98G cells are known for having high expression of the ACTA2 gene, which is involved in cell motility and structure.^[3] T98G cells are polyploidy variants of the parent T98 cell line, and can stay in the G1 phase of the cell cycle under stationary conditions.^[1]

T98G cells have been investigated along with A172 cells for drug cytotoxicity,^[3] and were found to be resistant to cisplatin, with larger cytotoxic effects induced by viral-mediated production of the p53 protein.^[4]