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Skin disease of equines From Wikipedia, the free encyclopedia
Also known as Queensland itch, seasonal recurrent dermatitis (SSRD), summer itch or more technically, Culicoides hypersensitivity.
Sweet itch is a medical condition in equines caused by an allergic response to the bites of Culicoides midges. It may be found in horses and ponies, especially in the warmer regions. It may also occur, too, in other equines.[1] It is also found in Canada, Australia, the US and many other parts of the world.[2]
A hypersensitivity reaction to specific allergens (protein molecules causing an extreme immune response in sensitised individuals) in the saliva of Culicoides midges. There are multiple allergens involved,[3] although some works claim that the larger proteins (of molecular weight 65kDa) are the most important.[4] These allergens appear to be cross-reactive across many species of Culicoides - i.e. many different varieties of midges produce similar allergens, giving the same effects upon horses.[5]
The hypersensitivity response is mediated by IgE, an antibody produced by the horse's immune system which binds the allergens, causing a cascade production of histamine and cytokines which make the horse's skin inflamed and itchy. Of these, histamine appears the most important in the initial phase of reaction.[6]
Few treatments are fully efficacious once lesions have appeared. The only effective form of treatment is preventative - i.e. prevent further insect bites - so these techniques will also be discussed here. Treatments generally fall into one of the following categories:
Overall, the wide variety of treatments proposed leads to the conclusion that no one method is universally effective.
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