Sultopride

Sultopride (trade names Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia.^[2][3][4] It was launched by Sanofi-Aventis in 1976.^[2] Sultopride acts as a selective D₂ and D₃ receptor antagonist.^[5] It has also been shown to have clinically relevant affinity for the GHB receptor as well, a property it shares in common with amisulpride and sulpiride.^[6]

Sultopride

Clinical data
Trade names	Barnetil, Barnotil, Topral
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, IM
ATC code	N05AL02 (WHO)
Legal status
Legal status	BR: Class C1 (Other controlled substances)[1] In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life	3–5 hours
Identifiers
IUPAC name N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
CAS Number	53583-79-2 N
PubChem CID	5357
ChemSpider	5164 Y
UNII	AA0G3TW31W
KEGG	D08549 Y
ChEMBL	ChEMBL277945 Y
CompTox Dashboard (EPA)	DTXSID9023627
ECHA InfoCard	100.053.293
Chemical and physical data
Formula	C17H26N2O4S
Molar mass	354.47 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(c1cc(c(OC)cc1)C(=O)NCC2N(CC)CCC2)CC
InChI InChI=1S/C17H26N2O4S/c1-4-19-10-6-7-13(19)12-18-17(20)15-11-14(24(21,22)5-2)8-9-16(15)23-3/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,18,20) Y Key:UNRHXEPDKXPRTM-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Pharmacology

Sultopride

Site	Ki	Species	Ref
D2	1.6	Human	[7]
D3	3.8	Human	[7]