Streptomyces toxytricini

Streptomyces toxytricini is a Gram-positive bacterium belonging to the genus Streptomyces. It produces the pancreatic lipase inhibitor lipstatin,^[1] of which the antiobesity drug orlistat is a derivative.^[2]

Streptomyces toxytricini
Scientific classification
Domain:	Bacteria
Phylum:	Actinomycetota
Class:	Actinomycetia
Order:	Streptomycetales
Family:	Streptomycetaceae
Genus:	Streptomyces
Species:	S. toxytricini
Binomial name
Streptomyces toxytricini Preobrazhenskaya & Sveshnikova 1957

References

1. Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987). "Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity". J Antibiot (Tokyo). 40 (8): 1081–5. doi:10.7164/antibiotics.40.1081. PMID 3680018.
2. Barbier P, Schneider F (1987). "Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin". Helvetica Chimica Acta. 70 (1): 196–202. doi:10.1002/hlca.19870700124.

Further reading

• Zhu, Tingheng; Wang, Lingfei; Wang, Weixia; Hu, Zhongce; Yu, Meilan; Wang, Kun; Cui, Zhifeng (April 3, 2014). "Enhanced production of lipstatin from Streptomyces toxytricini by optimizing fermentation conditions and medium". Journal of General and Applied Microbiology. 60 (3): 106–111. doi:10.2323/jgam.60.106. PMID 25008166.

External links

• Type strain of Streptomyces toxytricini at BacDive - the Bacterial Diversity Metadatabase