Sodium-coupled neutral amino acid transporter 3

Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.^[5][6][7]

SLC38A3
Identifiers
Aliases	SLC38A3, G17, NAT1, SN1, SNAT3, solute carrier family 38 member 3
External IDs	OMIM: 604437; MGI: 1923507; HomoloGene: 4983; GeneCards: SLC38A3; OMA:SLC38A3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,205,246 bp[1] End 50,221,486 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 58.69 cM Start 107,527,833 bp[2] End 107,546,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver muscle of thigh body of pancreas C1 segment ganglionic eminence right frontal lobe ventricular zone gastrocnemius muscle caudate nucleus amygdala Top expressed in neural layer of retina left lobe of liver Epithelium of choroid plexus muscle of thigh soleus muscle lumbar subsegment of spinal cord right ventricle superior frontal gyrus primary visual cortex ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function L-glutamine transmembrane transporter activity L-histidine transmembrane transporter activity L-asparagine transmembrane transporter activity L-alanine transmembrane transporter activity antiporter activity symporter activity amino acid transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane basolateral plasma membrane Biological process L-alanine transport sodium ion transport histidine transport female pregnancy positive regulation of transcription from RNA polymerase II promoter in response to acidic pH positive regulation of glutamine transport brain development asparagine transport amino acid transport cellular response to potassium ion starvation glutamine transport ion transport amino acid transmembrane transport transmembrane transport L-histidine transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10991 76257 Ensembl ENSG00000188338 ENSMUSG00000010064 UniProt Q99624 Q9DCP2 RefSeq (mRNA) NM_006841 NM_001199217 NM_001199218 NM_023805 RefSeq (protein) NP_006832 NP_001186146 NP_001186147 NP_076294 Location (UCSC) Chr 3: 50.21 – 50.22 Mb Chr 9: 107.53 – 107.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000188338 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010064 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chaudhry FA, Reimer RJ, Krizaj D, Barber D, Storm-Mathisen J, Copenhagen DR, Edwards RH (Feb 2000). "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission". Cell. 99 (7): 769–80. doi:10.1016/S0092-8674(00)81674-8. PMID 10619430. S2CID 17639583.
6. Fei YJ, Sugawara M, Nakanishi T, Huang W, Wang H, Prasad PD, Leibach FH, Ganapathy V (Sep 2000). "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter". J Biol Chem. 275 (31): 23707–17. doi:10.1074/jbc.M002282200. PMID 10823827.
7. "Entrez Gene: SLC38A3 solute carrier family 38, member 3".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Boehmer C, Okur F, Setiawan I, et al. (2003). "Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB". Biochem. Biophys. Res. Commun. 306 (1): 156–62. doi:10.1016/S0006-291X(03)00921-5. PMID 12788082.
• Sidoryk M, Matyja E, Dybel A, et al. (2004). "Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas". NeuroReport. 15 (4): 575–8. doi:10.1097/00001756-200403220-00001. PMID 15094455. S2CID 24489896.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Kholodnyuk ID, Kozireva S, Kost-Alimova M, et al. (2006). "Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice". Int. J. Cancer. 119 (1): 99–107. doi:10.1002/ijc.21794. PMID 16432833. S2CID 27171340.
• Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997.