Small nucleolar RNA SNORD90

In molecular biology, snoRNA SNORD90 (HBII-295) is a non-coding RNA that belongs to the family of C/D snoRNAs. Initially described as HBII-295^[1] this RNA has now been called SNORD70 by the HUGO Gene Nomenclature Committee. It is the human orthologue of the mouse MBII-295 and has no identified RNA target.^[2] This RNA is expressed from an intron of the MNAB/OR1K1 gene.

Small nucleolar RNA SNORD90
Predicted secondary structure and sequence conservation of SNORD90
Identifiers
Symbol	SNORD90
Alt. Symbols	snoHBII-295
Rfam	RF00579
Other data
RNA type	Gene; snRNA; snoRNA; C/D-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

There is evidence that SNORD90 is involved in guiding N6-methyladenosine (m6A) modifications onto target RNA transcripts.^[3] Specifically, SNORD90 has been shown to increase m6A levels on neuregulin 3 (NRG3) leading to its down-regulation through recognition by YTHDF2.^[3]