Small multidrug resistance protein

Small multidrug resistance protein (also known as Drug/Metabolite Transporter) is a family of integral membrane proteins that confer drug resistance to a wide range of toxic compounds by removing them for the cells. The efflux is coupled to an influx of protons. An example is Escherichia coli mvrC P23895 which prevents the incorporation of methyl viologen into cells^[1] and is involved in ethidium bromide efflux.^[2]

Small Multidrug Resistance protein
Identifiers
Symbol	Multi_Drug_Res
Pfam	PF00892
Pfam clan	CL0184
InterPro	IPR000390
SCOP2	1s7b / SCOPe / SUPFAM
TCDB	2.A.7
OPM superfamily	70
OPM protein	5i20
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

References

1. Morimyo M, Hongo E, Hama-inaba H, Machida I (1992). "Cloning and characterization of the mvrC gene of Escherichia coli K-12 which confers resistance against methyl viologen toxicity". Nucleic Acids Res. 20 (12): 3159–3165. doi:10.1093/nar/20.12.3159. PMC 312453. PMID 1320256.
2. Purewal AS (1991). "Nucleotide sequence of the ethidium efflux gene from Escherichia coli". FEMS Microbiol. Lett. 66 (2): 229–231. doi:10.1111/j.1574-6968.1991.tb04870.x. PMID 1936950.

This article incorporates text from the public domain Pfam and InterPro: IPR000390