Simon is a surname. Notable people with the surname include the following.
- Calvin Simon (1942–2022), American musician
- Carlos Eugênio Simon (born 1965), Brazilian FIFA football referee
- Carly Simon (born 1943), American singer-songwriter/musician
- Carrie Obendorfer Simon (1872–1961), American communal leader
- Chase Simon (born 1989), American basketball player for Maccabi Ashdod of the Israeli Basketball Premier League
- Chris Simon (born 1972), Canadian ice hockey player
- Claude Simon (1913–2005), French novelist
- Cliff Simon (1962–2021), South African athlete and actor
- Corey Simon (born 1977), former American football player
- Cosette Simon, American politician
- Danny Simon (1918–2005), American television writer
- David Simon (basketball) (born 1982), American basketball player
- David Simon (CEO), American CEO of Simon Property Group
- David Simon, Baron Simon of Highbury (born 1935), British businessman
- David Simon (writer) (born 1960), American author and journalist
- Dean Simon (born 1960), American professional wrestler better known as Dean Malenko
- Dick Simon (born 1933), American racing driver
- Dick Simon (entrepreneur) (born 1953), American entrepreneur, philanthropist, photographer and speaker
- Diederik Simon (born 1970), Dutch rower
- Diosdado Simón (1954–2002), Spanish biologist
- Dominik Simon (born 1994), Czech ice hockey player
- Edgardo Simón (born 1974), Argentinian track and road cyclist
- Edward Simon (choreographer), American choreographer
- Edward Simon (musician) (born 1969), American musician
- Eleazar ben Simon, 1st century Zealot leader
- Émilie Simon (born 1978), French singer and composer
- Ernest Simon, 1st Baron Simon of Wythenshawe (1879–1960), British industrialist and politician
- Ernst Simon (1899–1988), German-Israeli Jewish educator
- Ernst Julius Walter Simon (1893–1981), British Sinologist
- Eugène Simon (1848–1924), French arachnologist
- Evan Simon, American football player
- Ingo Simon (1875–1964), English archer, singer, and writer
- Jayci Simon (born 2005), American para-badminton player
- Jean-Claude Simon (born 1948), French research scientist
- Jeanne Hurley Simon (1922–2000), American politician
- Jed Simon (born 1964), Canadian musician
- Jennings Richard Simon (1929–2017),[1] American psychologist and engineer, and namesake of the Simon Effect
- Jerry Simon (born 1968), American-Israeli basketball player
- Joanna Simon (mezzo-soprano) (1936–2022), American mezzo-soprano and journalist
- Joanna Simon (wine writer), British author and wine columnist
- Jocelyn Simon, Baron Simon of Glaisdale (1911–2006), British politician and QC
- Jody Simon (born 1956), American professional wrestler better known as Joe Malenko
- Joe Simon (1913–2011), Jewish-American comic book writer
- Joe Simon (musician) (1936–2021), American soul and R&B artist
- John Simon various, including :
- Joseph Minos Simon (1922–2004), American attorney
- Josef Simon (1930–2016), German philosopher
- Joseph Simon (politician) (1851–1935), German-born American politician
- Josette Simon (born 1960), British actress
- Joshua Simon, Israeli art curator and journalist from Tel Aviv
- Jules Simon (1814–1896), French statesman and philosopher
- Julián Simón (born 1987), Spanish motorcycle racer
- Julian Lincoln Simon (1932–1998), American business professor
- Justin Simon (born 1996), American basketball player
- Lawrence Simon (1933–1994), American professional wrestler better known as Boris Malenko (also father of Dean and Jody Simon, aka Dean and Joe Malenko)
- Leon Simon (born 1945), Australian mathematician, professor at Stanford
- Leon Simon (Zionist) (1881–1965), British intellectual and civil servant; President of the Hebrew University of Jerusalem
- Leslie Earl Simon (1900–1983), American scientist
- Lidia Șimon (born 1973), Romanian long-distance athlete
- Lou Anna Simon, American, President of Michigan State University
- Lowrell Simon (1943–2018), American singer (of The Lost Generation (band))
- Lucy Simon (1943–2022), American singer
- Marcel Simon (actor) (1872–1958), Belgian actor
- María Simón (1922–2009), Argentine sculptor
- Maria Simon (actress) (born 1976), German actress
- Maria Simon (sociologist) (1918–2022), Austrian sociologist
- Marie Simon (1824–1877), German nurse
- Marge Simon (born 1942), American artist and writer
- Matilda Simon, 3rd Baroness Simon of Wythenshawe (born 1955), first British transgender peer
- Melissa Simon, American clinical obstetrician/gynecologist
- Melvin Simon (1926–2009), American real estate developer and film producer
- Melvin Simon (basketball) (born 1971), American professional basketball player
- Melvin I. Simon (born 1937), American molecular biologist and geneticist
- Michel Simon (1895–1975), Swiss actor
- Mike Simon (1883–1963), American baseball player
- Miles Simon (born 1975), American basketball player
- Lady Rachel Simon (1823–1899), British writer
- Rachel Simon (born 1959), American writer
- Ralph Simon, South African business executive
- Randall Simon (born 1975), Major League baseball player from Netherlands Antilles
- Raymond Simon, American educator
- Richard Simon (priest) (1638–1712), French biblical critic
- Richard Simon (painter) (1898–1993), German expressionist painter, pseudonym Simmerl
- Richard L. Simon (1899–1960), American businessman
- Roberlandy Simon (born 1987), Cuban volleyball player
- Robert E. Simon (1914–2015), American property developer
- Roger L. Simon (born 1943), American author
- Roger Simon (journalist) (born 1948), American journalist and author
- Roger Simon, 2nd Baron Simon of Wythenshawe (1913–2002), British solicitor and journalist
- S. J. Simon (1904–1948), British author
- Sam Simon (1955–2015), American television producer and writer
- Scott Simon (born 1952), American journalist
- Shena Simon, Lady Simon of Wythenshawe (1883–1972), British politician, feminist, educationalist and writer
- Simone Simon (1910–2005), French film actress
- Sindee Simon, American chemical engineer
- Siôn Simon (born 1968), British Labour Party politician
- Stephen Simon (1937–2013), American conductor, composer, and arranger of classical music
- Mark Simon, a character in the 1998 American science-fiction disaster movie Deep Impact