Shearinine

Shearinines A,D,E,and F, are marine fungal isolates with anticancer activity in vitro. They were isolated from a stain of Penicillium janthinellum Biourge. Their potential anticancer activity has been suggested by their induction of apoptosis in HL-60 cells.^[1] Shearinines D, E and G have also been found to block activity on large-conductance calcium-activated potassium channels.^[2]

Shearinines A,D,E,and F

References

1. Smetanina OF, et al. (Jun 2007). "Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge". J Nat Prod. 70 (6): 906–9. doi:10.1021/np060396d. PMID 17555349.
2. Xu, Minjuan; et al. (Jan 2007). "Shearinines D–K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channels". Tetrahedron. 63 (2): 435–444. doi:10.1016/j.tet.2006.10.050.