Serralysin

Serralysin (EC 3.4.24.40, Pseudomonas aeruginosa alkaline proteinase, Escherichia freundii proteinase, Serratia marcescens extracellular proteinase, Serratia marcescens metalloproteinase, Pseudomonas aeruginosa alk. protease, Serratia marcescens metalloprotease) is an enzyme.^{[1][2][3][4][5][6][7][8]} This enzyme catalyses the following chemical reaction

Preferential cleavage of bonds with hydrophobic residues in P1'

Serralysin
Identifiers
EC no.	3.4.24.40
CAS no.	70851-98-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This extracellular endopeptidase is present in Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi.

References

1. Morihara K, Tsuzuki H, Oka T (March 1968). "Comparison of the specificities of various neutral proteinases from microorganisms". Archives of Biochemistry and Biophysics. 123 (3): 572–88. doi:10.1016/0003-9861(68)90179-3. PMID 4967801.
2. Morihara K, Tsuzuki H, Oka T (June 1973). "On the specificity of Pseudomonas aeruginosa alkaline proteinase with synthetic peptides". Biochimica et Biophysica Acta (BBA) - Enzymology. 309 (2): 414–29. doi:10.1016/0005-2744(73)90040-5. PMID 4199986.
3. Nakajima M, Mizusawa K, Yoshida F (May 1974). "Purification and properties of an extracellular proteinase of psychrophilic Escherichia freundii". European Journal of Biochemistry. 44 (1): 87–96. doi:10.1111/j.1432-1033.1974.tb03460.x. PMID 4212288.
4. Decedue CJ, Broussard EA, Larson AD, Braymer HD (August 1979). "Purification and characterization of the extracellular proteinase of Serratia marcescens". Biochimica et Biophysica Acta (BBA) - Enzymology. 569 (2): 293–301. doi:10.1016/0005-2744(79)90065-2. PMID 383155.
5. Doerr M, Traub WH (May 1984). "Purification and characterization of two Serratia marcescens proteases". Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology. 257 (1): 6–19. PMID 6380155.
6. Nakahama K, Yoshimura K, Marumoto R, Kikuchi M, Lee IS, Hase T, Matsubara H (July 1986). "Cloning and sequencing of Serratia protease gene". Nucleic Acids Research. 14 (14): 5843–55. doi:10.1093/nar/14.14.5843. PMC 311595. PMID 3016665.
7. Dahler GS, Barras F, Keen NT (October 1990). "Cloning of genes encoding extracellular metalloproteases from Erwinia chrysanthemi EC16". Journal of Bacteriology. 172 (10): 5803–15. doi:10.1128/jb.172.10.5803-5815.1990. PMC 526898. PMID 2211513.
8. Okuda K, Morihara K, Atsumi Y, Takeuchi H, Kawamoto S, Kawasaki H, Suzuki K, Fukushima J (December 1990). "Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455". Infection and Immunity. 58 (12): 4083–8. doi:10.1128/IAI.58.12.4083-4088.1990. PMC 313780. PMID 2123832.

External links

• Serralysin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)