Secretin receptor

The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the secretin receptor family, also called class B GPCR subfamily.^[5]

SCTR
Identifiers
Aliases	SCTR, SR, secretin receptor
External IDs	OMIM: 182098; MGI: 2441720; HomoloGene: 68290; GeneCards: SCTR; OMA:SCTR - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.2 Start 119,439,843 bp[1] End 119,525,301 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 119,934,624 bp[2] End 119,991,266 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas testicle islet of Langerhans duodenum right lung upper lobe of left lung body of stomach human kidney gallbladder right uterine tube Top expressed in muscle of thigh epithelium of stomach morula knee joint lumbar subsegment of spinal cord soleus muscle tibialis anterior muscle vastus lateralis muscle temporal muscle upper arm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity secretin receptor activity peptide hormone binding G protein-coupled peptide receptor activity Cellular component integral component of membrane cytoplasmic microtubule plasma membrane membrane Biological process cell surface receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway brain development diet induced thermogenesis cellular water homeostasis response to nutrient levels regulation of appetite positive regulation of cAMP-mediated signaling regulation of synaptic plasticity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6344 319229 Ensembl ENSG00000080293 ENSMUSG00000026387 UniProt P47872 Q5FWI2 RefSeq (mRNA) NM_002980 NM_001012322 NM_001311077 RefSeq (protein) NP_002971 NP_001012322 NP_001298006 Location (UCSC) Chr 2: 119.44 – 119.53 Mb Chr 1: 119.93 – 119.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

The secretin receptor has been shown to interact with pituitary adenylate cyclase activating peptide.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000080293 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026387 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Receptors & Channels. 8 (3–4): 189–200. doi:10.1080/10606820213686. PMID 12529936.
6. Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT (December 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". The American Journal of Physiology. 263 (6 Pt 1): G901-7. doi:10.1152/ajpgi.1992.263.6.G901. PMID 1335692.

Further reading

• Ulrich CD, Holtmann M, Miller LJ (February 1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors". Gastroenterology. 114 (2): 382–97. doi:10.1016/S0016-5085(98)70491-3. PMID 9453500.
• Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT (December 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". The American Journal of Physiology. 263 (6 Pt 1): G901-7. doi:10.1152/ajpgi.1992.263.6.G901. PMID 1335692.
• Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S (July 1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor". The EMBO Journal. 10 (7): 1635–41. doi:10.1002/j.1460-2075.1991.tb07686.x. PMC 452832. PMID 1646711.
• Robberecht P, De Neef P, Waelbroeck M, Camus JC, Scemama JL, Fourmy D, Pradayrol L, Vaysse N, Christophe J (1988). "Secretin receptors in human pancreatic membranes". Pancreas. 3 (5): 529–35. doi:10.1097/00006676-198810000-00004. PMID 3186683. S2CID 23220534.
• Chow BK (July 1995). "Molecular cloning and functional characterization of a human secretin receptor". Biochemical and Biophysical Research Communications. 212 (1): 204–11. doi:10.1006/bbrc.1995.1957. PMID 7612008.
• Patel DR, Kong Y, Sreedharan SP (March 1995). "Molecular cloning and expression of a human secretin receptor". Molecular Pharmacology. 47 (3): 467–73. PMID 7700244.
• Holtmann MH, Hadac EM, Miller LJ (June 1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors". The Journal of Biological Chemistry. 270 (24): 14394–8. doi:10.1074/jbc.270.24.14394. PMID 7782300.
• Jiang S, Ulrich C (February 1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor". Biochemical and Biophysical Research Communications. 207 (3): 883–90. doi:10.1006/bbrc.1995.1268. PMID 7864894.
• Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (June 1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochemical and Biophysical Research Communications. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245.
• Mark HF, Chow BK (October 1995). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry". Genomics. 29 (3): 817–8. doi:10.1006/geno.1995.9922. PMID 8575789.
• Vilardaga JP, di Paolo E, de Neef P, Waelbroeck M, Bollen A, Robberecht P (January 1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin". Biochemical and Biophysical Research Communications. 218 (3): 842–6. doi:10.1006/bbrc.1996.0150. PMID 8579602.
• Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & Signal Transduction. 7 (3): 143–50. PMID 9440501.
• Shetzline MA, Premont RT, Walker JK, Vigna SR, Caron MG (March 1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor". The Journal of Biological Chemistry. 273 (12): 6756–62. doi:10.1074/jbc.273.12.6756. PMID 9506976.
• Ho PK, Fong RS, Kai HS, Lau EH, Ngan ES, Cotton CU, Chow BK (July 1999). "The human secretin receptor gene: genomic organization and promoter characterization". FEBS Letters. 455 (3): 209–14. doi:10.1016/S0014-5793(99)00864-9. PMID 10437774. S2CID 1197008.
• Pang RT, Ng SS, Cheng CH, Holtmann MH, Miller LJ, Chow BK (November 1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor". Endocrinology. 140 (11): 5102–11. doi:10.1210/endo.140.11.7134. PMID 10537138.
• Chan KY, Pang RT, Chow BK (September 2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor". Endocrinology. 142 (9): 3926–34. doi:10.1210/endo.142.9.8389. PMID 11517171.
• Pang RT, Lee LT, Ng SS, Yung WH, Chow BK (February 2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene". Molecular Endocrinology. 18 (2): 471–83. doi:10.1210/me.2003-0245. PMID 14645499.

External links

• IUPHAR GPCR Database - Secretin receptor Archived 2016-03-03 at the Wayback Machine
• secretin+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)