Sebaceous adenoma

Sebaceous adenomais a type of adenoma, characterized by a slow-growing tumor usually presenting as a pink, flesh-coloured, or yellow papule or nodule.^{[1]: 662 [2]}

Sebaceous adenoma
Micrograph of a sebaceous adenoma. H&E stain.
Specialty	Dermatology

Significance

Sebaceous adenomas, in isolation, are not significant; however, they may be associated with Muir-Torre syndrome, a genetic condition that predisposes individuals to cancer.^[3] It is also linked to hereditary nonpolyposis colorectal cancer (Lynch syndrome).

It is not the same as "adenoma sebaceum" by F. Balzer and P.E. Ménétrier (1885).^[4] The term "adenoma sebaceum" is a misnomer for facial angiofibromas associated with tuberous sclerosis complex.^{[5][lower-alpha 1][lower-alpha 2]}

See also

• Sebaceous carcinoma
• Sebaceous hyperplasia
• List of cutaneous conditions
• List of cutaneous neoplasms associated with systemic syndromes

Notes

1. Balzer and Menetrier (1885) described the microscopic appearance of the facial papules as "adenoma sebaceum", thought to be benign tumors of sebaceous glands, although the skin lesions are angiofibromas.
2. Facial angiofibromas were first described in 1885 by Balzer and Menetrier. At this time, they were incorrectly termed adenoma sebaceum. We now know that the sebaceous glands are only passively involved, if at all. Facial angiofibromas are hamartomas, defined as benign, tumorous nodules of superfluous tissue.

References

1. James et al. 2006
2. Rapini et al. 2007
3. Online Mendelian Inheritance in Man (OMIM): 158320
4. Balzer et al. 1885
5. Morgan et al. 1979

Sources

• Balzer F.; Ménétrier P. (1885). "Étude sur un cas d'adénomes sébacés de la face et du cuir". Archives de Physiologie normale et pathologique. 6 (3). Paris: 564–676.
• James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
• Morgan, J.E.; Wolfort F. (1979). "The Early History of Tuberous Sclerosis". Arch Dermatol. 115 (11): 1317–1319. doi:10.1001/archderm.1979.04010110023018. PMID 389165.
• Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1702, 1703. ISBN 978-1-4160-2999-1.
• Sami, David; Vivian, Antony; Taylor, David; Saunders, Down (1993). "36. The Phakomatoses". In Duane, Thomas (ed.). Duane's Clinical Ophthalmology. Vol. 5. Lippincott Williams & Wilkins. ISBN 039757245X.
• "Treatment of tuberous sclerosis complex dermatological lesions" (PDF). Tuberous Sclerosis Alliance, Derm Outreach Packet, p.7. tsalliance.org. 11 December 2008. Retrieved 2015-03-08.

External links