Sargsyan (Armenian: Սարգսյան, Armenian pronunciation: [sɑɾkʰəsˈjɑn]), also Sarkisian, Sarkissian (in Western Armenian Սարգիսեան, Armenian pronunciation: [sɑɾkʰisˈjɑn]) or Sarkisyan, is an Armenian surname derived from the given name Sargis (from the Latin Sergius).
People bearing this surname include:
- Anna M. Sargsyan (born 2001), Armenian chess master
- Ara Sargsian, (1902–1969) Armenian sculptor
- Aram Gaspar Sargsyan (born 1949), Armenian politician, a communist and social-democrat activist
- Aram Sargsyan (born 1961), Armenian Prime Minister 1999–2000
- Aram Sargsyan (singer) (born 1984), Armenian singer-songwriter, comedian and TV personality better known as Aram Mp3
- Armen Sargsyan (born 1953), Armenian Prime Minister 1996 to 1997
- Arsen Sargsyan (born 1984), Armenian long jumper
- Arthur Sargsyan (1968–2017), Armenian handcraft master, activist.
- Fadey Sargsyan (1923–2010), Armenian scientist and politician. Chairman of the Council of Ministers of the Armenian Soviet Socialist Republic from 1977 to 1989, later President of the Armenian National Academy of Sciences from 1993 to 2006.
- Gabriel Sargsyan (born 1983), Armenian chess player and International Grandmaster of Chess (2002)
- Gagik Sargsyan (1926–1998), Armenian historian, academic, vice-president of the Armenian Academy of Sciences
- Gevorg Sargsyan (born 1981), Armenian orchestra conductor
- Inessa Sargsyan (born 1972), Russian Armenian female volleyball player
- Karen Sargsyan (conductor), Armenian choir conductor
- Karen Sargsyan (footballer) (born 1983), Russian football player
- Narek Sargsyan (born 1958), chief architect of Yerevan
- Rita Sargsyan, wife of Armenian President Serzh Sargsyan, First Lady of Armenia
- Serzh Sargsyan (born 1954), Armenian politician, Armenian Prime Minister (2007–2008) and President (2008–2018)
- Shushanna Sargsyan (born 1992), Armenian chess player
- Sos Sargsyan (1929–2013), Armenian actor, People's Artist of the Soviet Union (1985) and People's Artist of Armenia
- Srbuhi Sargsyan (born 1994), Armenian singer known as Srbuk
- Tigran Sargsyan (born 1960), Armenian politician and Prime Minister of Armenia (2008–2014)
- Vahram Sargsyan (born 1981), Armenian composer and conductor
- Vardan Sargsyan (1875–1955), Soviet architect
- Vazgen Sargsyan (1959–1999), Armenian military commander, politician and writer, government minister and Prime Minister in 1999
- Vigen Sargsyan (born 1975), Armenian Defense Minister
- Vladimir Sargsyan (1935–2013) Soviet, Armenian scientist in the field of mechanics
- Andy Serkis, English film actor, director and author of English and Iraqi/Armenian descent was born with an Anglicised version of Sarkisian
- Alex Sarkisian (1922–2004), American football player
- Amy Sarkisian (born 1969), artist living and working in Los Angeles, California
- Cher (born Cherilyn Sarkisian in 1946), American performer
- Mark Sarkisian, American civil engineer
- Peter Sarkisian (born 1965), American video and multimedia artist
- Steve Sarkisian (born 1974), current University of Texas Longhorns football head coach and former University of Southern California Trojans football head coach
- Roza Sarkisian (born 1987), Ukrainian theater director and curator
- Adrian Sarkissian (born 1979), Uruguayan footballer
- Alexander Sarkissian (born 1990), American tennis player
- Ararat Sarkissian (born 1956), Armenian artist
- Armen Sarkissian (born 1953), Armenian politician, ambassador, Prime Minister of Armenia (1996–1997), President of Armenia (2018–2022)
- Arthur Sarkissian (born 1960), Armenian artist and painter
- Karnig Sarkissian, Armenian singer
- Ophelia Sarkissian, fictional character in Marvel Comics, better known as Viper or Madame Hydra
- Setrak Sarkissian, Lebanese Tabla player
- Serge Torsarkissian, Lebanese Armenian lawyer, politician, Member of Parliament (representing the Armenian Catholic seat in Beirut)
- Margos Sarkissian character of Terminator: The Sarah Connor Chronicles
- Janis Sarkisian, a character in the Broadway musical Mean Girls
- Ophelia Sarkissian, the alter ego of Viper, a supervillainess in Marvel Comics