Sangamo Therapeutics
American cell and gene therapy company From Wikipedia, the free encyclopedia
Sangamo Therapeutics, Inc. (previously known as Sangamo Biosciences, Inc.) is an American biotechnology company based in Brisbane, California. It applies cell and gene therapy to combat haemophilia and other genetic diseases.[2]
 | |
| Company type | Public |
|---|---|
| Nasdaq: SGMO Russell 2000 Index component | |
| Industry | Biotechnology |
| Founded | 1995 |
| Headquarters | Brisbane, California, US |
Key people | Sandy Macrae (CEO) Edward Rebar (CTO) |
| Revenue |  $111.3 million[1] (2022) |
| -$201.281 million[1] (2022) | |
| $192.3 million[1] (2022) | |
| Total assets |  $562.5 million[1] (2022) |
| Total equity | $294.958 million[1] (2022) |
Number of employees | 354 |
| Website | sangamo |
| Footnotes / references [1] | |
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The company was founded in 1995 in Richmond, California.[3] It was originally known as Sangamo Biosciences, Inc. before changing names in 2017. In September 2018, it had 182 employees.[3] Sandy Macrae is the president.[4] In 2018, Edward Rebar became the senior vice president and chief technology officer of Sangamo.[5]
Sangamo applies technology to treat haemophilia B and lysosomal storage diseases including mucopolysaccharidosis type I (Hurler Syndrome) and mucopolysaccharidosis type II (Hunter Syndrome). The FDA granted Sangamo fast track designation for SB-525, a gene therapy candidate for haemophilia A. In its partnership with Pfizer in 2017,[6] Sangamo uses Bioverativ in hemoglobinopathies such as beta thalassemia and sickle cell disease.[2] It is also developing zinc finger gene editing technology.[7]
In February 2019, medical scientists, working with Sangamo Therapeutics, announced the first ever "in body" human gene editing therapy to permanently alter DNA - in a patient with Hunter syndrome.[8] As of February 2019[update] clinical trials by Sangamo involving gene editing using zinc finger nuclease were ongoing.[9]
Sangamo's programs are a mix of wholly owned and partnered; major partners include Pfizer, Biogen, Sanofi, Takeda, and Kite (a Gilead company).[10][2][11][12]
As of 2020 Sangamo had the following clinical trials underway in the US:
- Phase 1/2 Thales study in beta thalassemia[13]
- Phase 1/2 STAAR study in Fabry disease[14]
- Phase 1/2 PRECIZN-1 study in sickle cell disease[15]
- Phase 1/2 CHAMPIONS study in MPS II[16]
- Phase 1/2 EMPOWERS study in MPS I[17]
- Phase 1/2 Alta study in hemophilia A[18]
- Phase 1 FIXTENDZ study in hemophilia B[19]
In February 2023, Sangamo Therapeutics announced that it would stop the late-stage development for the Phase 1/2 PRECIZN-1 study of BIVV003 its sickle cell drug.[20]
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