SULT1A3

Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene.^[3][4][5]

SULT1A3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1CJM, 2A3R,%%s1CJM
Identifiers
Aliases	SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST, ST1A3, sulfotransferase family 1A member 3, ST1A4
External IDs	OMIM: 600641; HomoloGene: 133085; GeneCards: SULT1A3; OMA:SULT1A3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,199,228 bp[1] End 30,204,310 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum mucosa of transverse colon granulocyte right hemisphere of cerebellum spleen rectum right lobe of liver right lobe of thyroid gland Pituitary Gland left lobe of thyroid gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity sulfotransferase activity protein binding aryl sulfotransferase activity sulfate binding amine sulfotransferase activity Cellular component cytoplasm cytosol Biological process steroid metabolic process IRE1-mediated unfolded protein response catecholamine metabolic process sulfation lipid metabolism flavonoid metabolic process xenobiotic metabolic process ethanol catabolic process dopamine receptor signaling pathway dopamine catabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process ERK1 and ERK2 cascade calcineurin-mediated signaling NMDA selective glutamate receptor signaling pathway negative regulation of neuron death cellular response to dopamine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6818 n/a Ensembl ENSG00000261052 n/a UniProt P0DMM9 P0DMN0 n/a RefSeq (mRNA) NM_001017387 NM_003166 NM_177552 n/a RefSeq (protein) NP_808220 NP_001017390 NP_001017390.1 NP_808220.1 NP_001017390 n/a Location (UCSC) Chr 16: 30.2 – 30.2 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). Three alternatively spliced variants that encode the same protein have been described.^[5]