STK33

Serine/threonine kinase 33 is a protein that in humans is encoded by the STK33 gene.

STK33
Identifiers
Aliases	STK33, serine/threonine kinase 33
External IDs	OMIM: 607670; MGI: 2152419; HomoloGene: 75307; GeneCards: STK33; OMA:STK33 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 8,391,868 bp[1] End 8,594,289 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.21 cM Start 108,878,430 bp[2] End 109,038,288 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary bronchial epithelial cell left testis right testis olfactory zone of nasal mucosa sperm gonad ventricular zone testicle Top expressed in spermatid spermatocyte seminiferous tubule epithelium of bronchiole spermatogonium medial ganglionic eminence embryo embryo Jacobson's organ outer plexiform layer More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity ATP binding kinase activity protein serine/threonine kinase activity Cellular component cytoplasm perinuclear region of cytoplasm intracellular anatomical structure nucleus Biological process protein autophosphorylation protein phosphorylation phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction signal transduction in response to DNA damage mitotic DNA damage checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65975 117229 Ensembl ENSG00000130413 ENSMUSG00000031027 UniProt Q9BYT3 Q924X7 RefSeq (mRNA) NM_001289058 NM_001289059 NM_001289061 NM_030906 NM_001352387 NM_001352388 NM_001352389 NM_001352390 NM_001352391 NM_001352392 NM_001352393 NM_001352394 NM_001352395 NM_001352396 NM_001352397 NM_001352398 NM_001352399 NM_054103 NM_001355145 RefSeq (protein) NP_001275987 NP_001275988 NP_001275990 NP_112168 NP_001339316 NP_001339317 NP_001339318 NP_001339319 NP_001339320 NP_001339321 NP_001339322 NP_001339323 NP_001339324 NP_001339325 NP_001339326 NP_001339327 NP_001339328 NP_473444 NP_001342074 Location (UCSC) Chr 11: 8.39 – 8.59 Mb Chr 7: 108.88 – 109.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

STK33 was identified as a synthetic lethal gene in KRAS-dependent cell lines.^[5]

STK33 has been considered as a target for reversible male contraceptives and the inhibitor CDD-2807 has been tested successfully in mice.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000130413 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031027 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, et al. (2010). "Screen for Inhibitors of STK33 Kinase Activity". Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). PMID 23658944.
6. "Drug causes reversible male contraception in mice". 10 June 2024.

External links

• STK33+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)