STK10

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.^[5][6]

STK10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J7T, 4AOT, 4BC6, 4EQU, 4USD, 4USE, 5AJQ
Identifiers
Aliases	STK10, LOK, PRO2729, serine/threonine kinase 10
External IDs	OMIM: 603919; MGI: 1099439; HomoloGene: 38122; GeneCards: STK10; OMA:STK10 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.1 Start 172,042,079 bp[1] End 172,188,224 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 18.97 cM|11 A4 Start 32,483,305 bp[2] End 32,574,587 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte sural nerve blood monocyte spleen cerebellar hemisphere right hemisphere of cerebellum bone marrow cells upper lobe of left lung lymph node Top expressed in granulocyte mesenteric lymph nodes blood spleen sciatic nerve seminiferous tubule decidua bone marrow intestinal villus external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity kinase activity protein binding identical protein binding ATP binding protein serine/threonine kinase activity Cellular component cytoplasm membrane extracellular exosome plasma membrane specific granule membrane Biological process lymphocyte aggregation phosphorylation regulation of lymphocyte migration protein autophosphorylation cell cycle protein phosphorylation neutrophil degranulation regulation of mitotic cell cycle signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6793 20868 Ensembl ENSG00000072786 ENSMUSG00000020272 UniProt O94804 O55098 RefSeq (mRNA) NM_005990 NM_009288 NM_001359177 NM_001359178 RefSeq (protein) NP_005981 NP_033314 NP_001346106 NP_001346107 Location (UCSC) Chr 5: 172.04 – 172.19 Mb Chr 11: 32.48 – 32.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.^[6]