SPPL2B

Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.^[5]

SPPL2B
Identifiers
Aliases	SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B
External IDs	OMIM: 608239; MGI: 1920468; HomoloGene: 10605; GeneCards: SPPL2B; OMA:SPPL2B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,328,615 bp[1] End 2,355,095 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,691,109 bp[2] End 80,704,542 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary left testis right testis right hemisphere of cerebellum transverse colon right lobe of thyroid gland body of pancreas left lobe of thyroid gland mucosa of transverse colon Top expressed in spermatocyte fetal liver hematopoietic progenitor cell spermatid motor neuron saccule neural layer of retina otic vesicle otic placode external carotid artery Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity aspartic-type endopeptidase activity peptidase activity protein binding hydrolase activity aspartic endopeptidase activity, intramembrane cleaving Cellular component integral component of membrane endosome centrosome Golgi apparatus membrane integral component of cytoplasmic side of endoplasmic reticulum membrane Golgi membrane nucleoplasm lysosomal membrane actin cytoskeleton Golgi-associated vesicle membrane lysosome integral component of lumenal side of endoplasmic reticulum membrane endosome membrane plasma membrane Biological process membrane protein proteolysis proteolysis membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis regulation of immune response regulation of tumor necrosis factor-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56928 73218 Ensembl ENSG00000005206 ENSMUSG00000035206 UniProt Q8TCT7 Q3TD49 RefSeq (mRNA) NM_001077238 NM_152988 NM_175195 NM_001358803 NM_001358804 RefSeq (protein) NP_001070706 NP_694533 NP_780404 NP_001345732 NP_001345733 Location (UCSC) Chr 19: 2.33 – 2.36 Mb Chr 10: 80.69 – 80.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the signal peptide peptidase-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This enzyme localizes to endosomes, lysosomes, and the plasma membrane. This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells.^[6][7] SPPL2b also modulates APP cleavage and Aβ production.^[8] Multiple transcript variants encoding different isoforms have been found for this gene.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000005206 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035206 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SPPL2B signal peptide peptidase-like 2B".
6. Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol. 8 (8): 843–8. doi:10.1038/ncb1440. PMID 16829952. S2CID 129089.
7. Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b". Nat. Cell Biol. 8 (8): 894–6. doi:10.1038/ncb1450. PMID 16829951. S2CID 23712486.
8. Maccioni, Riccardo; Travisan, Caterina; Badman, Jack; Zerial, Stefania; Wagener, Annika; Andrade-Talavera, Yuniesky; Picciau, Federico; Grassi, Caterina; Chen, Gefei; Lemoine, Laetitia; Fisahn, André; Jiang, Richeng; Fluhrer, Regina; Mentrup, Torben; Schröder, Bernd (April 2024). "Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease". Progress in Neurobiology. 235: 102585. doi:10.1016/j.pneurobio.2024.102585.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Weihofen A, Binns K, Lemberg MK, et al. (2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science. 296 (5576): 2215–8. Bibcode:2002Sci...296.2215W. doi:10.1126/science.1070925. PMID 12077416. S2CID 45633906.
• Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI (2003). "Novel class of polytopic proteins with domains associated with putative protease activity". Biochemistry Mosc. 67 (7): 826–35. doi:10.1023/A:1016365227942. PMID 12139484. S2CID 11785597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824. S2CID 4420825.
• Friedmann E, Lemberg MK, Weihofen A, et al. (2005). "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins". J. Biol. Chem. 279 (49): 50790–8. doi:10.1074/jbc.M407898200. hdl:2262/89311. PMID 15385547.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Krawitz P, Haffner C, Fluhrer R, et al. (2006). "Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3". J. Biol. Chem. 280 (47): 39515–23. doi:10.1074/jbc.M501645200. PMID 15998642.
• Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b" (PDF). Nat. Cell Biol. 8 (8): 894–6. doi:10.1038/ncb1450. PMID 16829951. S2CID 23712486.
• Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol. 8 (8): 843–8. doi:10.1038/ncb1440. PMID 16829952. S2CID 129089.