SPPL2B

Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.^[5]

SPPL2B
Identifiers
Aliases	SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B
External IDs	OMIM: 608239; MGI: 1920468; HomoloGene: 10605; GeneCards: SPPL2B; OMA:SPPL2B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,328,615 bp[1] End 2,355,095 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,691,109 bp[2] End 80,704,542 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary left testis right testis right hemisphere of cerebellum transverse colon right lobe of thyroid gland body of pancreas left lobe of thyroid gland mucosa of transverse colon Top expressed in spermatocyte fetal liver hematopoietic progenitor cell spermatid motor neuron saccule neural layer of retina otic vesicle otic placode external carotid artery Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity aspartic-type endopeptidase activity peptidase activity protein binding hydrolase activity aspartic endopeptidase activity, intramembrane cleaving Cellular component integral component of membrane endosome centrosome Golgi apparatus membrane integral component of cytoplasmic side of endoplasmic reticulum membrane Golgi membrane nucleoplasm lysosomal membrane actin cytoskeleton Golgi-associated vesicle membrane lysosome integral component of lumenal side of endoplasmic reticulum membrane endosome membrane plasma membrane Biological process membrane protein proteolysis proteolysis membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis regulation of immune response regulation of tumor necrosis factor-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56928 73218 Ensembl ENSG00000005206 ENSMUSG00000035206 UniProt Q8TCT7 Q3TD49 RefSeq (mRNA) NM_001077238 NM_152988 NM_175195 NM_001358803 NM_001358804 RefSeq (protein) NP_001070706 NP_694533 NP_780404 NP_001345732 NP_001345733 Location (UCSC) Chr 19: 2.33 – 2.36 Mb Chr 10: 80.69 – 80.7 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the signal peptide peptidase-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This enzyme localizes to endosomes, lysosomes, and the plasma membrane. This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells.^[6][7] SPPL2b also modulates APP cleavage and Aβ production.^[8] Multiple transcript variants encoding different isoforms have been found for this gene.^[5]