SPINT1

Kunitz-type protease inhibitor 1 is an enzyme that in humans is encoded by the SPINT1 gene.^[5]

SPINT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YC0, 2MSX, 4ISL, 4ISN, 4ISO, 5EZD
Identifiers
Aliases	SPINT1, HAI, HAI1, MANSC2, serine peptidase inhibitor, Kunitz type 1
External IDs	OMIM: 605123; MGI: 1338033; HomoloGene: 9653; GeneCards: SPINT1; OMA:SPINT1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 40,844,018 bp[1] End 40,858,207 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 119,067,843 bp[2] End 119,080,008 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon jejunal mucosa skin of abdomen skin of leg minor salivary glands duodenum olfactory zone of nasal mucosa rectum islet of Langerhans right uterine tube Top expressed in left colon duodenum crypt of lieberkuhn of small intestine transitional epithelium of urinary bladder ileum lip corneal stroma jejunum vestibular membrane of cochlear duct esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular exosome membrane extracellular space plasma membrane Biological process negative regulation of peptidase activity negative regulation of endopeptidase activity neural tube closure embryonic placenta development extracellular matrix organization positive regulation of glial cell differentiation branching involved in labyrinthine layer morphogenesis placenta blood vessel development cellular response to BMP stimulus negative regulation of neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6692 20732 Ensembl ENSG00000166145 ENSMUSG00000027315 UniProt O43278 Q9R097 RefSeq (mRNA) NM_001032367 NM_003710 NM_181642 NM_001386873 NM_001386874 NM_001386875 NM_016907 RefSeq (protein) NP_001027539 NP_003701 NP_857593 NP_058603 Location (UCSC) Chr 15: 40.84 – 40.86 Mb Chr 2: 119.07 – 119.08 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.^[5]