SPINLW1

Eppin is a protein that in humans is encoded by the SPINLW1 gene.^[5][6][7]

EPPIN
Identifiers
Aliases	EPPIN, CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2, epididymal peptidase inhibitor
External IDs	OMIM: 609031; MGI: 2684968; HomoloGene: 128601; GeneCards: EPPIN; OMA:EPPIN - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,540,626 bp[1] End 45,547,752 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,421,439 bp[2] End 164,427,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis corpus epididymis left testis buccal mucosa cell epithelium of bronchus bronchial epithelial cell tail of epididymis mucosa of paranasal sinus olfactory zone of nasal mucosa gonad Top expressed in testicle spermatocyte urinary bladder lung spermatid ovary adrenal gland uterus white adipose tissue stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity Cellular component extracellular region cell surface extracellular space sperm plasma membrane protein-containing complex Biological process negative regulation of calcium ion import negative regulation of peptidase activity defense response to bacterium protein complex oligomerization negative regulation of endopeptidase activity negative regulation of flagellated sperm motility antimicrobial humoral response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57119 209351 Ensembl ENSG00000101448 ENSMUSG00000074595 UniProt O95925 Q3UW55 RefSeq (mRNA) NM_181502 NM_001302861 NM_020398 NM_001033240 NM_001177848 RefSeq (protein) NP_001289790 NP_065131 NP_001185915 NP_001028412 NP_001171319 Location (UCSC) Chr 20: 45.54 – 45.55 Mb Chr 2: 164.42 – 164.43 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[7]