SPINLW1

Eppin is a protein that in humans is encoded by the SPINLW1 gene.^[5][6][7]

EPPIN
Identifiers
Aliases	EPPIN, CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2, epididymal peptidase inhibitor
External IDs	OMIM: 609031; MGI: 2684968; HomoloGene: 128601; GeneCards: EPPIN; OMA:EPPIN - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,540,626 bp[1] End 45,547,752 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,421,439 bp[2] End 164,427,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis corpus epididymis left testis buccal mucosa cell epithelium of bronchus bronchial epithelial cell tail of epididymis mucosa of paranasal sinus olfactory zone of nasal mucosa gonad Top expressed in testicle spermatocyte urinary bladder lung spermatid ovary adrenal gland uterus white adipose tissue stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity Cellular component extracellular region cell surface extracellular space sperm plasma membrane protein-containing complex Biological process negative regulation of calcium ion import negative regulation of peptidase activity defense response to bacterium protein complex oligomerization negative regulation of endopeptidase activity negative regulation of flagellated sperm motility antimicrobial humoral response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57119 209351 Ensembl ENSG00000101448 ENSMUSG00000074595 UniProt O95925 Q3UW55 RefSeq (mRNA) NM_181502 NM_001302861 NM_020398 NM_001033240 NM_001177848 RefSeq (protein) NP_001289790 NP_065131 NP_001185915 NP_001028412 NP_001171319 Location (UCSC) Chr 20: 45.54 – 45.55 Mb Chr 2: 164.42 – 164.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000101448 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074595 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Richardson RT, Sivashanmugam P, Hall SH, Hamil KG, Moore PA, Ruben SM, French FS, O'Rand M (Jun 2001). "Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis". Gene. 270 (1–2): 93–102. doi:10.1016/S0378-1119(01)00462-0. PMID 11404006.
6. Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC 1222987. PMID 12206714.
7. "Entrez Gene: SPINLW1 serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)".

Further reading

• Wang Z, Widgren EE, Sivashanmugam P, et al. (2005). "Association of eppin with semenogelin on human spermatozoa". Biol. Reprod. 72 (5): 1064–70. doi:10.1095/biolreprod.104.036483. PMID 15590901.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yenugu S, Richardson RT, Sivashanmugam P, et al. (2005). "Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif". Biol. Reprod. 71 (5): 1484–90. doi:10.1095/biolreprod.104.031567. PMID 15229136.
• Sivashanmugam P, Hall SH, Hamil KG, et al. (2003). "Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2". Gene. 312: 125–34. doi:10.1016/S0378-1119(03)00608-5. PMID 12909348.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.