SPECC1

Cytospin-B is a protein that, in humans, is encoded by the CYTSB gene.^[5][6][7][8]

SPECC1
Identifiers
Aliases	SPECC1, CYTSB, HCMOGT-1, HCMOGT1, NSP, sperm antigen with calponin homology and coiled-coil domains 1, NSP5
External IDs	OMIM: 608793; MGI: 2442356; HomoloGene: 45157; GeneCards: SPECC1; OMA:SPECC1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 20,008,865 bp[1] End 20,319,026 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B2 Start 61,847,589 bp[2] End 62,113,839 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum C1 segment sural nerve testicle globus pallidus internal globus pallidus external globus pallidus substantia nigra gonad Top expressed in blood molar motor neuron fetal liver hematopoietic progenitor cell lumbar subsegment of spinal cord superior colliculus inferior colliculi cerebellar cortex anterior horn of spinal cord deep cerebellar nuclei More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 92521 432572 Ensembl ENSG00000128487 ENSMUSG00000042331 UniProt Q5M775 Q5SXY1 RefSeq (mRNA) NM_001033553 NM_001033554 NM_001033555 NM_001243438 NM_001243439 NM_152904 NM_001386077 NM_001386078 NM_001386079 NM_001386080 NM_001386081 NM_001386082 NM_001386083 NM_001386084 NM_001386085 NM_001029936 NM_001281818 NM_001310526 RefSeq (protein) NP_001028725 NP_001028726 NP_001028727 NP_001230367 NP_001230368 NP_690868 NP_001025107 NP_001268747 NP_001297455 Location (UCSC) Chr 17: 20.01 – 20.32 Mb Chr 11: 61.85 – 62.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000128487 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042331 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sang N, Fath DM, Giordano A (Dec 2004). "A gene highly expressed in tumor cells encodes novel structure proteins". Oncogene. 23 (58): 9438–46. doi:10.1038/sj.onc.1207988. PMC 4518866. PMID 15602574.
6. D'Agostino L, Giordano A (Aug 2008). "Possible functional role of NSPs in cancer". Cell Cycle. 7 (12): 1810–27. doi:10.4161/cc.7.12.6023. PMID 18763323.
7. Morerio C, Acquila M, Rosanda C, Rapella A, Dufour C, Locatelli F, Maserati E, Pasquali F, Panarello C (Apr 2004). "HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2)". Cancer Res. 64 (8): 2649–51. doi:10.1158/0008-5472.CAN-03-4026. PMID 15087372.
8. "Entrez Gene: SPECC1 sperm antigen with calponin homology and coiled-coil domains 1".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.