SOCS7

Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.^[5][6][7]

SOCS7
Identifiers
Aliases	SOCS7, NAP4, NCKAP4, suppressor of cytokine signaling 7
External IDs	OMIM: 608788; MGI: 2651588; HomoloGene: 16331; GeneCards: SOCS7; OMA:SOCS7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 38,351,844 bp[1] End 38,405,593 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 97,253,261 bp[2] End 97,289,368 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis cerebellum cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum ganglionic eminence sural nerve islet of Langerhans skeletal muscle tissue Top expressed in seminiferous tubule Rostral migratory stream secondary oocyte zygote primary oocyte neural layer of retina cerebellar vermis nucleus of stria terminalis lobe of cerebellum epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein kinase inhibitor activity protein binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component plasma membrane membrane nucleus cytoplasm cytosol phosphatidylinositol 3-kinase complex Biological process insulin receptor signaling pathway regulation of growth negative regulation of signal transduction intracellular signal transduction cerebral cortex radially oriented cell migration layer formation in cerebral cortex fat cell differentiation protein ubiquitination negative regulation of protein kinase activity cytokine-mediated signaling pathway radial glia guided migration of Purkinje cell negative regulation of receptor signaling pathway via JAK-STAT biological process regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30837 192157 Ensembl ENSG00000274229 ENSG00000274211 ENSMUSG00000038485 UniProt O14512 Q8VHQ2 RefSeq (mRNA) NM_014598 NM_138657 RefSeq (protein) NP_055413 NP_619598 Location (UCSC) Chr 17: 38.35 – 38.41 Mb Chr 11: 97.25 – 97.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SOCS7 has been shown to interact with NCK1.^[5]

References

1. ENSG00000274211 GRCh38: Ensembl release 89: ENSG00000274229, ENSG00000274211 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038485 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
6. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
7. "Entrez Gene: SOCS7 suppressor of cytokine signaling 7".

Further reading

• Cooney RN (Feb 2002). "Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway". Shock. 17 (2): 83–90. doi:10.1097/00024382-200202000-00001. PMID 11837794. S2CID 40940132.
• Wormald S, Hilton DJ (Jan 2004). "Inhibitors of cytokine signal transduction" (PDF). The Journal of Biological Chemistry. 279 (2): 821–4. doi:10.1074/jbc.R300030200. PMID 14607831. S2CID 3469978.
• Fujimoto M, Naka T (Dec 2003). "Regulation of cytokine signaling by SOCS family molecules". Trends in Immunology. 24 (12): 659–66. doi:10.1016/j.it.2003.10.008. PMID 14644140.
• Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA (Jan 1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proceedings of the National Academy of Sciences of the United States of America. 95 (1): 114–9. Bibcode:1998PNAS...95..114H. doi:10.1073/pnas.95.1.114. PMC 18144. PMID 9419338.
• Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R (Sep 2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines". Journal of Neuroimmunology. 109 (1): 34–9. doi:10.1016/S0165-5728(00)00300-3. PMID 10969179. S2CID 23752435.
• Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS (Jul 2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation". Molecular and Cellular Biology. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
• Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, Vandenhaute J, Hooghe-Peters EL (Aug 2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin". Experimental Cell Research. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID 15242778.
• Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A (Apr 2005). "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation". The Journal of Biological Chemistry. 280 (14): 13817–23. doi:10.1074/jbc.M411596200. PMID 15677474.
• Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB (Sep 2005). "Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans". The Journal of Clinical Investigation. 115 (9): 2462–71. doi:10.1172/JCI23853. PMC 1190369. PMID 16127460.
• Kremer BE, Adang LA, Macara IG (Sep 2007). "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7". Cell. 130 (5): 837–50. doi:10.1016/j.cell.2007.06.053. PMC 2085444. PMID 17803907.