SNX27

Sorting nexin family member 27, also known as SNX27, is a human gene.^[5]

SNX27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HAS
Identifiers
Aliases	SNX27, MRT1, MY014, sorting nexin family member 27, sorting nexin 27
External IDs	OMIM: 611541; MGI: 1923992; HomoloGene: 12797; GeneCards: SNX27; OMA:SNX27 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 151,612,006 bp[1] End 151,699,091 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 94,404,851 bp[2] End 94,490,023 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus optic nerve external globus pallidus superior vestibular nucleus inferior ganglion of vagus nerve lateral nuclear group of thalamus ventral tegmental area subthalamic nucleus monocyte pars compacta Top expressed in otic vesicle tail of embryo otolith organ utricle Rostral migratory stream ventromedial nucleus lateral septal nucleus dentate gyrus of hippocampal formation granule cell hand spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding protein binding phosphatidylinositol binding lipid binding Cellular component early endosome membrane membrane nucleoplasm retromer complex early endosome immunological synapse WASH complex cytoplasm endosome cytosol Biological process establishment of natural killer cell polarity endosome to lysosome transport endosomal transport protein transport intracellular protein transport signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81609 76742 Ensembl ENSG00000143376 ENSMUSG00000028136 UniProt Q96L92 Q3UHD6 RefSeq (mRNA) NM_030918 NM_001330723 NM_001082484 NM_029721 RefSeq (protein) NP_001317652 NP_112180 NP_001075953 NP_083997 Location (UCSC) Chr 1: 151.61 – 151.7 Mb Chr 3: 94.4 – 94.49 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.^[5]