SNRPB

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.^[5][6]

SNRPB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D3B, 3CW1, 3PGW, 4PJO, 4WZJ, 3JCR
Identifiers
Aliases	SNRPB, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, CCMS, small nuclear ribonucleoprotein polypeptides B and B1
External IDs	OMIM: 182282; MGI: 98342; HomoloGene: 134543; GeneCards: SNRPB; OMA:SNRPB - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 2,461,634 bp[1] End 2,470,853 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.19 cM Start 130,013,555 bp[2] End 130,021,323 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon mucosa of esophagus skin of leg skin of abdomen thymus left uterine tube mucosa of pharynx lymph node gingival epithelium Top expressed in choroid plexus of fourth ventricle somite lactiferous gland abdominal wall mandibular prominence maxillary prominence primitive streak entorhinal cortex embryo CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone pre-mRNA DCP binding U2 snRNA binding protein binding telomerase RNA binding RNA binding U1 snRNP binding U2 snRNP binding Cellular component cytoplasm SMN-Sm protein complex cytosol catalytic step 2 spliceosome U4/U6 x U5 tri-snRNP complex histone pre-mRNA 3'end processing complex U5 snRNP U12-type spliceosomal complex U2 snRNP U1 snRNP methylosome U7 snRNP small nuclear ribonucleoprotein complex telomerase holoenzyme complex spliceosomal complex U4 snRNP extracellular exosome U2-type prespliceosome nucleus nucleoplasm U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing spliceosomal snRNP assembly RNA splicing histone mRNA metabolic process protein methylation import into nucleus brain development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6628 20638 Ensembl ENSG00000125835 ENSMUSG00000027404 UniProt P14678 P27048 RefSeq (mRNA) NM_198216 NM_003091 NM_009225 RefSeq (protein) NP_003082 NP_937859 NP_033251 Location (UCSC) Chr 20: 2.46 – 2.47 Mb Chr 2: 130.01 – 130.02 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.^[6]

Interactions

SNRPB has been shown to interact with DDX20^[7] and Coilin.^[8]