SNRPB

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.^[5][6]

SNRPB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D3B, 3CW1, 3PGW, 4PJO, 4WZJ, 3JCR
Identifiers
Aliases	SNRPB, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, CCMS, small nuclear ribonucleoprotein polypeptides B and B1
External IDs	OMIM: 182282; MGI: 98342; HomoloGene: 134543; GeneCards: SNRPB; OMA:SNRPB - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 2,461,634 bp[1] End 2,470,853 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.19 cM Start 130,013,555 bp[2] End 130,021,323 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon mucosa of esophagus skin of leg skin of abdomen thymus left uterine tube mucosa of pharynx lymph node gingival epithelium Top expressed in choroid plexus of fourth ventricle somite lactiferous gland abdominal wall mandibular prominence maxillary prominence primitive streak entorhinal cortex embryo CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone pre-mRNA DCP binding U2 snRNA binding protein binding telomerase RNA binding RNA binding U1 snRNP binding U2 snRNP binding Cellular component cytoplasm SMN-Sm protein complex cytosol catalytic step 2 spliceosome U4/U6 x U5 tri-snRNP complex histone pre-mRNA 3'end processing complex U5 snRNP U12-type spliceosomal complex U2 snRNP U1 snRNP methylosome U7 snRNP small nuclear ribonucleoprotein complex telomerase holoenzyme complex spliceosomal complex U4 snRNP extracellular exosome U2-type prespliceosome nucleus nucleoplasm U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing spliceosomal snRNP assembly RNA splicing histone mRNA metabolic process protein methylation import into nucleus brain development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6628 20638 Ensembl ENSG00000125835 ENSMUSG00000027404 UniProt P14678 P27048 RefSeq (mRNA) NM_198216 NM_003091 NM_009225 RefSeq (protein) NP_003082 NP_937859 NP_033251 Location (UCSC) Chr 20: 2.46 – 2.47 Mb Chr 2: 130.01 – 130.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.^[6]

Interactions

SNRPB has been shown to interact with DDX20^[7] and Coilin.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000125835 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027404 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Griffith AJ, Schmauss C, Craft J (July 1992). "The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site". Gene. 114 (2): 195–201. doi:10.1016/0378-1119(92)90574-9. PMID 1376292.
6. "Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1".
7. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
8. Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (October 2001). "Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein". Genes Dev. 15 (20): 2720–9. doi:10.1101/gad.908401. PMC 312817. PMID 11641277.

Further reading

• Will CL, Lührmann R (2001). "Spliceosomal UsnRNP biogenesis, structure and function". Curr. Opin. Cell Biol. 13 (3): 290–301. doi:10.1016/S0955-0674(00)00211-8. hdl:11858/00-001M-0000-0012-F770-0. PMID 11343899.
• Schmauss C, Lerner MR (1990). "The closely related small nuclear ribonucleoprotein polypeptides N and B/B' are distinguishable by antibodies as well as by differences in their mRNAs and gene structures". J. Biol. Chem. 265 (18): 10733–9. doi:10.1016/S0021-9258(18)87008-9. PMID 1693924.
• Elkon KB, Hines JJ, Chu JL, Parnassa A (1990). "Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction". J. Immunol. 145 (2): 636–43. doi:10.4049/jimmunol.145.2.636. PMID 1694885.
• Chu JL, Elkon KB (1991). "The small nuclear ribonucleoproteins, SmB and B', are products of a single gene". Gene. 97 (2): 311–2. doi:10.1016/0378-1119(91)90069-N. PMID 1825643.
• Sharpe NG, Williams DG, Latchman DS (1990). "Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation". Mol. Cell. Biol. 10 (12): 6817–20. doi:10.1128/mcb.10.12.6817. PMC 362965. PMID 2174118.
• Schmauss C, McAllister G, Ohosone Y, Hardin JA, Lerner MR (1989). "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'". Nucleic Acids Res. 17 (4): 1733–43. doi:10.1093/nar/17.4.1733. PMC 331831. PMID 2522186.
• Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". J. Biol. Chem. 264 (10): 5776–83. doi:10.1016/S0021-9258(18)83617-1. PMID 2522439.
• Ohosone Y, Mimori T, Griffith A, Akizuki M, Homma M, Craft J, Hardin JA (1989). "Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4249–53. Bibcode:1989PNAS...86.4249O. doi:10.1073/pnas.86.11.4249. PMC 287428. PMID 2524838.
• van Dam A, Winkel I, Zijlstra-Baalbergen J, Smeenk R, Cuypers HT (1989). "Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part". EMBO J. 8 (12): 3853–60. doi:10.1002/j.1460-2075.1989.tb08563.x. PMC 402073. PMID 2531083.
• Huntriss JD, Latchman DS, Williams DG (1993). "Lupus autoantibodies discriminate between the highly homologous Sm polypeptides B/B' and SmN by binding an epitope restricted to B/B'". Clin. Exp. Immunol. 92 (2): 263–7. doi:10.1111/j.1365-2249.1993.tb03390.x. PMC 1554819. PMID 7683587.
• Gerrelli D, Grimaldi K, Horn D, Mahadeva U, Sharpe N, Latchman DS (1993). "The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein". J. Mol. Cell. Cardiol. 25 (3): 321–9. doi:10.1006/jmcc.1993.1038. PMID 8510173.
• Simons A, Melamed-Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, Rotter V (1997). "PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb". Oncogene. 14 (2): 145–55. doi:10.1038/sj.onc.1200825. PMID 9010216.
• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. S2CID 10855404.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
• Bedford MT, Reed R, Leder P (1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10602–7. Bibcode:1998PNAS...9510602B. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
• Gray TA, Smithwick MJ, Schaldach MA, Martone DL, Graves JA, McCarrey JR, Nicholls RD (1999). "Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci". Nucleic Acids Res. 27 (23): 4577–84. doi:10.1093/nar/27.23.4577. PMC 148745. PMID 10556313.
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.