SLMAP

Sarcolemmal membrane-associated protein is a protein that in humans is encoded by the SLMAP gene.^[5][6][7]

SLMAP
Identifiers
Aliases	SLMAP, SLAP, sarcolemma associated protein
External IDs	OMIM: 602701; MGI: 1933549; HomoloGene: 31428; GeneCards: SLMAP; OMA:SLMAP - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.3 Start 57,755,450 bp[1] End 57,930,003 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 26,413,168 bp[2] End 26,534,931 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein tail of epididymis cardiac muscle tissue of right atrium myocardium of left ventricle smooth muscle tissue seminal vesicula vena cava right ventricle popliteal artery tibial arteries Top expressed in tunica media of zone of aorta cardiac muscle tissue of left ventricle ascending aorta olfactory tubercle atrioventricular valve aortic valve left colon atrium iris nucleus accumbens More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component smooth endoplasmic reticulum cytoplasm integral component of membrane sarcolemma plasma membrane integral component of plasma membrane cytoskeleton membrane microtubule organizing center Biological process muscle contraction protein localization to plasma membrane regulation of membrane depolarization during cardiac muscle cell action potential regulation of sodium ion transmembrane transport regulation of voltage-gated sodium channel activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7871 83997 Ensembl ENSG00000163681 ENSMUSG00000021870 UniProt Q14BN4 Q3URD3 RefSeq (mRNA) NM_001304420 NM_001304421 NM_001304422 NM_001304423 NM_001311178 NM_001311179 NM_007159 NM_001377538 NM_001377539 NM_001377540 NM_001377541 NM_001377542 NM_001377545 NM_001377549 NM_001377551 NM_001377552 NM_001377555 NM_001377557 NM_001377559 NM_001377562 NM_001377921 NM_001377922 NM_001377923 NM_001377924 NM_001377925 NM_001377926 NM_001377927 NM_001377928 NM_032008 NM_001310445 NM_001347494 RefSeq (protein) NP_001291349 NP_001291350 NP_001291351 NP_001291352 NP_001298107 NP_001298108 NP_009090 NP_001297374 NP_001334423 NP_114397 Location (UCSC) Chr 3: 57.76 – 57.93 Mb Chr 14: 26.41 – 26.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SLMAP has been shown to interact with STK24.^[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000163681 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021870 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wigle JT, Demchyshyn L, Pratt MA, Staines WA, Salih M, Tuana BS (December 19, 1997). "Molecular cloning, expression, and chromosomal assignment of sarcolemmal-associated proteins. A family of acidic amphipathic alpha-helical proteins associated with the membrane". J. Biol. Chem. 272 (51): 32384–94. doi:10.1074/jbc.272.51.32384. PMID 9405447.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
7. "Entrez Gene: SLMAP sarcolemma associated protein".
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
9. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

• Wielowieyski PA, Sevinc S, Guzzo R, Salih M, Wigle JT, Tuana BS (2000). "Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins". J. Biol. Chem. 275 (49): 38474–81. doi:10.1074/jbc.M007682200. PMID 10986292.
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.