SLC2A6

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.^[5][6]

SLC2A6
Identifiers
Aliases	SLC2A6, GLUT6, GLUT9, HSA011372, solute carrier family 2 member 6
External IDs	OMIM: 606813; MGI: 2443286; HomoloGene: 69236; GeneCards: SLC2A6; OMA:SLC2A6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,471,094 bp[1] End 133,479,127 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 26,911,375 bp[2] End 26,918,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte prefrontal cortex right frontal lobe primary visual cortex Brodmann area 9 blood superior frontal gyrus anterior cingulate cortex hypothalamus Top expressed in granulocyte lumbar spinal ganglion dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus facial motor nucleus blood cerebellar cortex morula embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glucose transmembrane transporter activity carbohydrate:proton symporter activity transmembrane transporter activity transporter activity D-glucose transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process carbohydrate transport glucose import transmembrane transport hexose transmembrane transport proton transmembrane transport glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11182 227659 Ensembl ENSG00000160326 ENSG00000281165 ENSMUSG00000036067 UniProt Q9UGQ3 Q3UDF0 RefSeq (mRNA) NM_001145099 NM_017585 NM_001177627 NM_172659 RefSeq (protein) NP_001138571 NP_060055 NP_001171098 NP_766247 Location (UCSC) Chr 9: 133.47 – 133.48 Mb Chr 2: 26.91 – 26.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM]^[6]

See also

• Glucose transporter
• Solute carrier family

References

1. ENSG00000281165 GRCh38: Ensembl release 89: ENSG00000160326, ENSG00000281165 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036067 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Doege H, Bocianski A, Joost HG, Schürmann A (September 2000). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes". The Biochemical Journal. 350 Pt 3 (Pt 3): 771–6. doi:10.1042/0264-6021:3500771. PMC 1221309. PMID 10970791.
6. "Entrez Gene: SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6".

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Richardson S, Neama G, Phillips T, Bell S, Carter SD, Moley KH, Moley JF, Vannucci SJ, Mobasheri A (February 2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthritis and Cartilage. 11 (2): 92–101. doi:10.1053/joca.2002.0858. PMID 12554125.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.