SLC22A25

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.^[5][6]

SLC22A25
Identifiers
Aliases	SLC22A25, HIMTP, UST6, solute carrier family 22 member 25
External IDs	OMIM: 610792; MGI: 2442750; HomoloGene: 77136; GeneCards: SLC22A25; OMA:SLC22A25 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 63,158,437 bp[1] End 63,243,599 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 8,312,735 bp[2] End 8,382,475 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver buccal mucosa cell gonad gallbladder nucleus accumbens vagina white blood cell myeloid leukocyte monocyte right frontal lobe Top expressed in proximal tubule right kidney human kidney liver gallbladder metanephros embryo primary oocyte neural layer of retina secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function sodium-independent organic anion transmembrane transporter activity inorganic anion exchanger activity urate transmembrane transporter activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane Biological process sodium-independent organic anion transport transmembrane transport inorganic anion transport urate transport organic anion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 387601 319800 Ensembl ENSG00000196600 ENSMUSG00000052562 UniProt Q6T423 n/a RefSeq (mRNA) NM_199352 NM_001394058 NM_001394059 NM_177002 RefSeq (protein) NP_955384 n/a Location (UCSC) Chr 11: 63.16 – 63.24 Mb Chr 19: 8.31 – 8.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000196600 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052562 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 22".
6. Jacobsson JA; Haitina T; Lindblom J; Fredriksson R (November 2007). "Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family". Genomics. 90 (5): 595–609. doi:10.1016/j.ygeno.2007.03.017. PMID 17714910.

Further reading

• Eraly SA; Monte JC; Nigam SK (2004). "Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters". Physiol. Genomics. 18 (1): 12–24. doi:10.1152/physiolgenomics.00014.2004. PMID 15054140. S2CID 11787759.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zaïr ZM; Eloranta JJ; Stieger B; Kullak-Ublick GA (2008). "Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney" (PDF). Pharmacogenomics. 9 (5): 597–624. doi:10.2217/14622416.9.5.597. PMID 18466105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.