SLC16A11

Monocarboxylate transporter 11 (MCT 11) is a protein that in humans is encode by the SLC16A11 gene.^[5]

SLC16A11
Identifiers
Aliases	SLC16A11, MCT11, solute carrier family 16 member 11, MCT 11
External IDs	OMIM: 615765; MGI: 2663709; HomoloGene: 27409; GeneCards: SLC16A11; OMA:SLC16A11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,041,621 bp[1] End 7,044,092 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 70,103,578 bp[2] End 70,107,243 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland left lobe of thyroid gland olfactory zone of nasal mucosa parotid gland minor salivary glands palpebral conjunctiva skin of abdomen skin of leg right lobe of liver Top expressed in cerebellar cortex right kidney olfactory epithelium motor neuron superior frontal gyrus trachea primary visual cortex conjunctival fornix dentate gyrus of hippocampal formation granule cell gastrula More reference expression data BioGPS n/a
Gene ontology Molecular function symporter activity monocarboxylic acid transmembrane transporter activity protein binding pyruvate transmembrane transporter activity Cellular component membrane integral component of membrane endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane plasma membrane Biological process transmembrane transport lipid metabolism monocarboxylic acid transport pyruvate transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 162515 216867 Ensembl ENSG00000174326 ENSMUSG00000040938 UniProt Q8NCK7 Q5NC32 RefSeq (mRNA) NM_153357 NM_001370549 NM_001370553 NM_001114970 NM_001114971 NM_153081 RefSeq (protein) NP_699188 NP_001357478 NP_001357482 NP_694721 Location (UCSC) Chr 17: 7.04 – 7.04 Mb Chr 11: 70.1 – 70.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Variants in this gene are associated with increased body-mass index^[6] and type 2 diabetes.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000174326 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040938 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "UniProt". www.uniprot.org. Retrieved 2024-07-16.
6. Mardones L, Petermann-Rocha F, Martinez-Sanguinetti MA, Leiva AM, Troncoso-Pantoja C, Martorell M, et al. (November 2021). "Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population". Archives of Endocrinology and Metabolism. 65 (3): 305–314. doi:10.20945/2359-3997000000359. PMC 10065347. PMID 33909378.
7. Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, et al. (February 2014). "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico". Nature. 506 (7486): 97–101. Bibcode:2014Natur.506...97T. doi:10.1038/nature12828. PMC 4127086. PMID 24390345.