SLC13A2

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.^[5][6][7]

SLC13A2
Identifiers
Aliases	SLC13A2, NADC1, NaCT, NaDC-1, SDCT1, solute carrier family 13 member 2
External IDs	OMIM: 604148; MGI: 1276558; HomoloGene: 2965; GeneCards: SLC13A2; OMA:SLC13A2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,473,293 bp[1] End 28,497,781 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,287,913 bp[2] End 78,313,043 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum testicle human kidney olfactory zone of nasal mucosa salivary gland minor salivary glands lactiferous duct mucosa of ileum mucosa of transverse colon Top expressed in intestinal villus jejunum right kidney left colon proximal tubule ileum human kidney conjunctival fornix morula epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function low-affinity sodium:dicarboxylate symporter activity symporter activity transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process ion transport sodium ion transport dicarboxylic acid transport transmembrane transport anion transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9058 20500 Ensembl ENSG00000007216 ENSMUSG00000001095 UniProt Q13183 Q9ES88 RefSeq (mRNA) NM_001145975 NM_001145976 NM_003984 NM_001346683 NM_001346684 NM_022411 RefSeq (protein) NP_001139447 NP_001333612 NP_001333613 NP_003975 NP_071856 Location (UCSC) Chr 17: 28.47 – 28.5 Mb Chr 11: 78.29 – 78.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000007216 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001095 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pajor AM (Dec 1996). "Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney". Am J Physiol. 270 (4 Pt 2): F642–8. doi:10.1152/ajprenal.1996.270.4.F642. PMID 8967342.
6. Mann SS, Hart TC, Pettenati MJ, von Kap-herr C, Holmes RP (Jun 1999). "Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1→q11.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 89–90. doi:10.1159/000015222. PMID 10343111. S2CID 26457719.
7. "Entrez Gene: SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2".

Further reading

• Inoue K, Zhuang L, Ganapathy V (2003). "Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function". Biochem. Biophys. Res. Commun. 299 (3): 465–71. doi:10.1016/S0006-291X(02)02669-4. PMID 12445824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bai X, Chen X, Fen Z, et al. (2005). "Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study". Science in China Series C: Life Sciences. 47 (6): 530–9. doi:10.1360/03yc0044. PMID 15620109. S2CID 36487757.
• Pajor AM, Randolph KM (2005). "Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter". J. Biol. Chem. 280 (19): 18728–35. doi:10.1074/jbc.M501265200. PMC 1224748. PMID 15774465.
• Okamoto N, Aruga S, Matsuzaki S, et al. (2007). "Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls". Int. J. Urol. 14 (4): 344–9. doi:10.1111/j.1442-2042.2007.01554.x. PMID 17470169. S2CID 41274929.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.