SLC12A9

Solute carrier family 12 member 9 (SLC12A9), also known as cation-chloride cotransporter 6 (CCC6) or cation-chloride cotransporter-interacting protein 1 (CIP1), is a protein that in humans is encoded by the SLC12A9 gene.^[5][6][7]

SLC12A9
Identifiers
Aliases	SLC12A9, CCC6, CIP1, WO3.3, hCCC6, solute carrier family 12 member 9
External IDs	OMIM: 616861; MGI: 1933532; HomoloGene: 5429; GeneCards: SLC12A9; OMA:SLC12A9 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,826,820 bp[1] End 100,867,010 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,314,558 bp[2] End 137,333,597 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen C1 segment mucosa of transverse colon right hemisphere of cerebellum body of uterus lymph node right ovary Top expressed in neural layer of retina granulocyte secondary oocyte yolk sac otic vesicle Rostral migratory stream primary oocyte internal carotid artery external carotid artery superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function potassium:chloride symporter activity transporter activity cation:chloride symporter activity Cellular component extracellular exosome plasma membrane membrane integral component of membrane Biological process ion transport transmembrane transport potassium ion transmembrane transport chloride transmembrane transport chloride transport transport cell volume homeostasis chloride ion homeostasis potassium ion homeostasis potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56996 83704 Ensembl ENSG00000146828 ENSMUSG00000037344 UniProt Q9BXP2 Q99MR3 RefSeq (mRNA) NM_001267812 NM_001267814 NM_020246 NM_001363493 NM_001363494 NM_031406 NM_001359611 RefSeq (protein) NP_001254741 NP_001254743 NP_064631 NP_001350422 NP_001350423 NP_113583 NP_001346540 Location (UCSC) Chr 7: 100.83 – 100.87 Mb Chr 5: 137.31 – 137.33 Mb PubMed search [3] [4]
Wikidata
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References

1. GRCh38: Ensembl release 89: ENSG00000146828 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037344 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 12 (potassium/chloride transporters)".
6. Caron L; Rousseau F; Gagnon E; Isenring P (October 2000). "Cloning and functional characterization of a cation-Cl⁻ cotransporter-interacting protein". J. Biol. Chem. 275 (41): 32027–36. doi:10.1074/jbc.M000108200. PMID 10871601.
7. Wilson MD; Riemer C; Martindale DW; Schnupf P; Boright AP; Cheung TL; Hardy DM; Schwartz S; Scherer SW; Tsui LC; Miller W; Koop BF (March 2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Res. 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.

Further reading

• Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, et al. (2010). "Genome-wide association analysis identifies multiple loci related to resting heart rate". Hum. Mol. Genet. 19 (19): 3885–94. doi:10.1093/hmg/ddq303. PMC 3657480. PMID 20639392.
• de Vries, H; Rüegsegger, U; Hübner, W; Friedlein, A; Langen, H; Keller, W (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.