SIGLEC10

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.^[5][6] Siglec-G is often referred to as the murine paralog of human Siglec-10 ^[7]

SIGLEC10
Identifiers
Aliases	SIGLEC10, PRO940, SIGLEC-10, SLG2, sialic acid binding Ig like lectin 10
External IDs	OMIM: 606091; MGI: 2443630; HomoloGene: 13228; GeneCards: SIGLEC10; OMA:SIGLEC10 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,410,020 bp[1] End 51,417,803 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 43,057,628 bp[2] End 43,067,782 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood appendix spleen oocyte secondary oocyte lymph node buccal mucosa cell right adrenal cortex Top expressed in mesenteric lymph nodes spleen granulocyte blood subcutaneous adipose tissue bone marrow pharynx morula submandibular gland blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding protein binding phosphatase binding SH2 domain binding Cellular component integral component of membrane extracellular region membrane plasma membrane Biological process cell adhesion adaptive immune response immune system process innate immune response negative regulation of inflammatory response to wounding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89790 243958 Ensembl ENSG00000142512 ENSMUSG00000030468 UniProt Q96LC7 Q80ZE3 RefSeq (mRNA) NM_001171156 NM_001171157 NM_001171158 NM_001171159 NM_001171160 NM_001171161 NM_033130 NM_001322105 NM_172900 NM_001382486 RefSeq (protein) NP_001164627 NP_001164628 NP_001164629 NP_001164630 NP_001164632 NP_001309034 NP_149121 NP_766488 NP_001369415 Location (UCSC) Chr 19: 51.41 – 51.42 Mb Chr 7: 43.06 – 43.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Structure and function

Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab.^[8] It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).

Gene family summary

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000142512 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030468 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Munday J, Kerr S, Ni J, Cornish AL, Zhang JQ, Nicoll G, Floyd H, Mattei MG, Moore P, Liu D, Crocker PR (Apr 2001). "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor". Biochem J. 355 (Pt 2): 489–97. doi:10.1042/0264-6021:3550489. PMC 1221762. PMID 11284738.
6. "Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10".
7. Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon M, Zhang W, Lenz HJ, Han Y, Amos CI, Syedbasha M, Egli A, Stenner F, Speiser DE, Varki A, Zippelius A, Läubli H (Nov 2018). "Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells". J. Clin. Invest. 128 (Pt 11): 4912–23. doi:10.1172/JCI120612. PMC 6205408. PMID 30130255.
8. Clark, M. & A. Cooke (2013). "Regulation unmasked by activation". Nat Immunol. 14 (7): 696–697. doi:10.1038/ni.2646. PMID 23778805. S2CID 11457712.

Further reading

• Li N, Zhang W, Wan T, et al. (2001). "Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells". J. Biol. Chem. 276 (30): 28106–12. doi:10.1074/jbc.M100467200. PMID 11358961.
• Yousef GM, Ordon MH, Foussias G, Diamandis EP (2001). "Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants". Biochem. Biophys. Res. Commun. 284 (4): 900–10. doi:10.1006/bbrc.2001.5053. PMID 11409878.
• Nagano T, Yoneda T, Hatanaka Y, et al. (2002). "Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone". Nat. Cell Biol. 4 (7): 495–501. doi:10.1038/ncb808. PMID 12055638. S2CID 4795393.
• Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J (2002). "Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1". Biochem. Biophys. Res. Commun. 296 (2): 355–62. doi:10.1016/S0006-291X(02)00885-9. PMID 12163025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.