SHB (gene)

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.^[5][6]

SHB
Identifiers
Aliases	SHB, bA3J10.2, SH2 domain containing adaptor protein B
External IDs	OMIM: 600314; MGI: 98294; HomoloGene: 74458; GeneCards: SHB; OMA:SHB - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.1 Start 37,915,898 bp[1] End 38,069,227 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 45,423,278 bp[2] End 45,532,470 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland gingival epithelium germinal epithelium amniotic fluid ganglionic eminence retinal pigment epithelium cartilage tissue hair follicle parietal pleura palpebral conjunctiva Top expressed in gastrula decidua ganglionic eminence zygote esophagus molar lip secondary oocyte medial ganglionic eminence left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphotyrosine residue binding protein binding Cellular component cytoplasm plasma membrane membrane nucleoplasm cytosol cytoplasmic ribonucleoprotein granule Biological process multicellular organism development cell differentiation vascular endothelial growth factor receptor signaling pathway angiogenesis apoptotic process positive regulation of signal transduction signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6461 230126 Ensembl ENSG00000107338 ENSMUSG00000044813 UniProt Q15464 Q6PD21 RefSeq (mRNA) NM_003028 NM_001033306 RefSeq (protein) NP_003019 NP_001028478 Location (UCSC) Chr 9: 37.92 – 38.07 Mb Chr 4: 45.42 – 45.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SHB (gene) has been shown to interact with:

• EPS8,^[7]
• Fibroblast growth factor receptor 1,^[7]
• Linker of activated T cells,^[8][9]
• Lymphocyte cytosolic protein 2,^[9]
• PIK3R1,^[7]
• Src,^[7]
• VAV1,^[9] and
• ZAP-70.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000107338 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044813 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yulug IG, Hillermann R, Fisher EM (Dec 1994). "The SHB adaptor protein maps to human chromosome 9". Genomics. 24 (3): 615–7. doi:10.1006/geno.1994.1681. PMID 7713524.
6. "Entrez Gene: SHB Src homology 2 domain containing adaptor protein B".
7. Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475–83. PMID 7537362.
8. Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". The Journal of Biological Chemistry. 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
9. Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.

Further reading

• Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475–83. PMID 7537362.
• Welsh M, Mares J, Karlsson T, Lavergne C, Bréant B, Claesson-Welsh L (Jan 1994). "Shb is a ubiquitously expressed Src homology 2 protein". Oncogene. 9 (1): 19–27. PMID 8302579.
• Karlsson T, Welsh M (Sep 1996). "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb". Oncogene. 13 (5): 955–61. PMID 8806685.
• Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene. 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780. S2CID 28452652.
• Karlsson T, Kullander K, Welsh M (Sep 1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells". Cell Growth & Differentiation. 9 (9): 757–66. PMID 9751119.
• Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". The Journal of Biological Chemistry. 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
• Dixelius J, Larsson H, Sasaki T, Holmqvist K, Lu L, Engström A, Timpl R, Welsh M, Claesson-Welsh L (Jun 2000). "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis". Blood. 95 (11): 3403–11. doi:10.1182/blood.V95.11.3403. PMID 10828022.
• Hooshmand-Rad R, Lu L, Heldin CH, Claesson-Welsh L, Welsh M (Jun 2000). "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization". Experimental Cell Research. 257 (2): 245–54. doi:10.1006/excr.2000.4896. PMID 10837138.
• Lu L, Annerén C, Reedquist KA, Bos JL, Welsh M (Sep 2000). "NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway". Experimental Cell Research. 259 (2): 370–7. doi:10.1006/excr.2000.4984. PMID 10964504. S2CID 31219631.
• Diakonova M, Gunter DR, Herrington J, Carter-Su C (Mar 2002). "SH2-Bbeta is a Rac-binding protein that regulates cell motility". The Journal of Biological Chemistry. 277 (12): 10669–77. doi:10.1074/jbc.M111138200. PMID 11786545.
• Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.
• Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L (Aug 2002). "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells". Molecular Biology of the Cell. 13 (8): 2881–93. doi:10.1091/mbc.E02-02-0103. PMC 117949. PMID 12181353.
• Lindholm CK (Aug 2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells". Biochemical and Biophysical Research Communications. 296 (4): 929–36. doi:10.1016/S0006-291X(02)02016-8. PMID 12200137.
• Holmqvist K, Cross M, Riley D, Welsh M (Feb 2003). "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells". Cellular Signalling. 15 (2): 171–9. doi:10.1016/S0898-6568(02)00076-1. PMID 12464388.
• Welsh N, Makeeva N, Welsh M (Nov 2002). "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins". Molecular Medicine. 8 (11): 695–704. doi:10.1007/BF03402033. PMC 2039954. PMID 12520086.
• Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M (May 2004). "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration". The Journal of Biological Chemistry. 279 (21): 22267–75. doi:10.1074/jbc.M312729200. PMID 15026417.