SGPP1

Sphingosine-1-phosphate phosphatase 1 is an enzyme that in humans is encoded by the SGPP1 gene.^[5][6]

SGPP1
Identifiers
Aliases	SGPP1, SPPase1, sphingosine-1-phosphate phosphatase 1, SPP-1
External IDs	OMIM: 612826; MGI: 2135760; HomoloGene: 101696; GeneCards: SGPP1; OMA:SGPP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.2 Start 63,684,216 bp[1] End 63,728,065 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 75,761,023 bp[2] End 75,782,503 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node placenta islet of Langerhans C1 segment endometrium human kidney right lobe of liver Brodmann area 9 Achilles tendon prefrontal cortex Top expressed in seminal vesicula lobe of prostate decidua lacrimal gland gastrula skin of abdomen proximal tubule parotid gland right kidney gastric mucosa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity sphingosine-1-phosphate phosphatase activity dihydrosphingosine-1-phosphate phosphatase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane plasma membrane nucleus nucleoplasm Biological process intrinsic apoptotic signaling pathway sphingosine metabolic process sphingolipid biosynthetic process extrinsic apoptotic signaling pathway dephosphorylation sphinganine-1-phosphate metabolic process sphingolipid metabolic process ER to Golgi ceramide transport regulation of keratinocyte differentiation regulation of epidermis development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81537 81535 Ensembl ENSG00000126821 ENSG00000285281 ENSMUSG00000021054 UniProt Q9BX95 Q9JI99 RefSeq (mRNA) NM_030791 NM_030750 RefSeq (protein) NP_110418 NP_109675 Location (UCSC) Chr 14: 63.68 – 63.73 Mb Chr 12: 75.76 – 75.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000285281 GRCh38: Ensembl release 89: ENSG00000126821, ENSG00000285281 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021054 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mandala SM, Thornton R, Galve-Roperh I, Poulton S, Peterson C, Olivera A, Bergstrom J, Kurtz MB, Spiegel S (Aug 2000). "Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death". Proc Natl Acad Sci U S A. 97 (14): 7859–64. Bibcode:2000PNAS...97.7859M. doi:10.1073/pnas.120146897. PMC 16635. PMID 10859351.
6. "Entrez Gene: SGPP1 sphingosine-1-phosphate phosphatase 1".

Further reading

• Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003). "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2". J. Biol. Chem. 278 (2): 1268–72. doi:10.1074/jbc.M209514200. PMID 12411432.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
• Johnson KR, Johnson KY, Becker KP, et al. (2003). "Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability". J. Biol. Chem. 278 (36): 34541–7. doi:10.1074/jbc.M301741200. PMID 12815058.
• Le Stunff H, Mikami A, Giussani P, et al. (2004). "Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis". J. Biol. Chem. 279 (33): 34290–7. doi:10.1074/jbc.M404907200. PMID 15180992.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Giussani P, Maceyka M, Le Stunff H, et al. (2006). "Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide". Mol. Cell. Biol. 26 (13): 5055–69. doi:10.1128/MCB.02107-05. PMC 1489178. PMID 16782891.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.