SEMA6A

Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.^[5][6][7]

SEMA6A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AFC, 3AL8, 3OKW, 3OKY
Identifiers
Aliases	SEMA6A, HT018, SEMA, SEMA6A1, SEMAQ, VIA, semaphorin 6A
External IDs	OMIM: 605885; MGI: 1203727; HomoloGene: 32426; GeneCards: SEMA6A; OMA:SEMA6A - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q23.1 Start 116,443,555 bp[1] End 116,574,823 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 C Start 47,368,665 bp[2] End 47,501,937 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve external globus pallidus subthalamic nucleus corpus callosum jejunal mucosa lateral nuclear group of thalamus pars reticulata ventral tegmental area superior vestibular nucleus pons Top expressed in tail of embryo genital tubercle lumbar subsegment of spinal cord yolk sac Dermatocranium membranous bone epiblast mandible cartilage of the septum medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding semaphorin receptor binding chemorepellent activity Cellular component integral component of membrane axon plasma membrane membrane integral component of plasma membrane extracellular space Biological process animal organ morphogenesis multicellular organism development cell surface receptor signaling pathway cell differentiation cytoskeleton organization nervous system development apoptotic process axon guidance positive regulation of neuron migration negative regulation of sprouting angiogenesis negative regulation of angiogenesis negative regulation of cell adhesion involved in sprouting angiogenesis cellular response to vascular endothelial growth factor stimulus negative regulation of ERK1 and ERK2 cascade negative regulation of vascular endothelial growth factor signaling pathway neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57556 20358 Ensembl ENSG00000092421 ENSMUSG00000019647 UniProt Q9H2E6 O35464 RefSeq (mRNA) NM_001300780 NM_020681 NM_020796 NM_018744 NM_001311097 RefSeq (protein) NP_001287709 NP_065847 NP_001298026 NP_061214 Location (UCSC) Chr 5: 116.44 – 116.57 Mb Chr 18: 47.37 – 47.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

In melanocytic cells SEMA6A gene expression may be regulated by MITF.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000092421 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019647 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou L, White FA, Lentz SI, Wright DE, Fisher DA, Snider WD (Sep 1997). "Cloning and expression of a novel murine semaphorin with structural similarity to insect semaphorin I". Mol Cell Neurosci. 9 (1): 26–41. doi:10.1006/mcne.1997.0607. PMID 9204478. S2CID 38730386.
6. Klostermann A, Lutz B, Gertler F, Behl C (Jan 2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain". J Biol Chem. 275 (50): 39647–53. doi:10.1074/jbc.M006316200. PMID 10993894.
7. "Entrez Gene: SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A".
8. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

• Prislei S, Mozzetti S, Filippetti F, et al. (2008). "From plasma membrane to cytoskeleton: a novel function for semaphorin 6A". Mol. Cancer Ther. 7 (1): 233–41. doi:10.1158/1535-7163.MCT-07-0390. PMID 18187809.
• Katoh M, Katoh M (2007). "Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells". Int. J. Mol. Med. 20 (3): 405–9. doi:10.3892/ijmm.20.3.405. PMID 17671748.
• Gautier G, de Saint-Vis B, Sénéchal B, et al. (2006). "The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations". Am. J. Pathol. 168 (2): 453–65. doi:10.2353/ajpath.2006.050288. PMC 1606484. PMID 16436660.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.