SEMA3C

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.^[5][6][7]

SEMA3C
Identifiers
Aliases	SEMA3C, SEMAE, SemE, semaphorin 3C
External IDs	OMIM: 602645; MGI: 107557; HomoloGene: 36201; GeneCards: SEMA3C; OMA:SEMA3C - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.11 Start 80,742,538 bp[1] End 80,922,359 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 17,779,279 bp[2] End 17,935,266 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lactiferous duct synovial joint Achilles tendon cartilage tissue germinal epithelium skin of hip vena cava synovial membrane tail of epididymis biceps brachii Top expressed in retinal pigment epithelium right lung lobe submandibular gland ankle medullary collecting duct left colon calvaria skin of external ear vas deferens seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function semaphorin receptor binding neuropilin binding chemorepellent activity Cellular component extracellular region extracellular exosome extracellular space integral component of plasma membrane Biological process somitogenesis cell differentiation limb bud formation outflow tract morphogenesis post-embryonic development nervous system development axon guidance multicellular organism development heart development blood vessel remodeling pulmonary myocardium development immune response neural tube development dichotomous subdivision of terminal units involved in salivary gland branching cardiac right ventricle morphogenesis neural crest cell migration negative chemotaxis outflow tract septum morphogenesis semaphorin-plexin signaling pathway cardiac endothelial to mesenchymal transition positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis positive regulation of cell migration negative regulation of axon extension involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10512 20348 Ensembl ENSG00000075223 ENSMUSG00000028780 UniProt Q99985 Q62181 RefSeq (mRNA) NM_006379 NM_001350120 NM_001350121 NM_013657 RefSeq (protein) NP_006370 NP_001337049 NP_001337050 NP_038685 Location (UCSC) Chr 7: 80.74 – 80.92 Mb Chr 5: 17.78 – 17.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000075223 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028780 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
6. Mangasser-Stephan K, Dooley S, Welter C, Mutschler W, Hanselmann RG (May 1997). "Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display". Biochemical and Biophysical Research Communications. 234 (1): 153–6. doi:10.1006/bbrc.1997.6607. PMID 9168980.
7. "Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C".

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348. S2CID 17985062.
• Yamada T, Endo R, Gotoh M, Hirohashi S (December 1997). "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14713–8. Bibcode:1997PNAS...9414713Y. doi:10.1073/pnas.94.26.14713. PMC 25101. PMID 9405678.
• Galani E, Sgouros J, Petropoulou C, Janinis J, Aravantinos G, Dionysiou-Asteriou D, Skarlos D, Gonos E (2002). "Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients". Anticancer Research. 22 (4): 2275–80. PMID 12174914.
• Rieger J, Wick W, Weller M (June 2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia. 42 (4): 379–89. doi:10.1002/glia.10210. PMID 12730958. S2CID 45643250.
• Miller LE, Weidler C, Falk W, Angele P, Schaumburger J, Schölmerich J, Straub RH (April 2004). "Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis". Arthritis and Rheumatism. 50 (4): 1156–63. doi:10.1002/art.20110. PMID 15077297.
• Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B (April 2005). "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis". International Journal of Cancer. 114 (4): 590–7. doi:10.1002/ijc.20798. PMID 15609325. S2CID 39883399.
• Herman JG, Meadows GG (May 2007). "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells". International Journal of Oncology. 30 (5): 1231–8. doi:10.3892/ijo.30.5.1231. PMID 17390026.