SCN4B

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.^[5] The protein is encoded by the SCN4B gene.^[6] Mutations in the SCN4B are associated with long QT syndrome.^[7]

SCN4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MZ2, 4MZ3
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256; MGI: 2687406; HomoloGene: 18384; GeneCards: SCN4B; OMA:SCN4B - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,133,377 bp[1] End 118,152,888 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 45,049,693 bp[2] End 45,065,450 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus spinal ganglia putamen right hemisphere of cerebellum Pons caudate nucleus lateral nuclear group of thalamus primary visual cortex Brodmann area 23 trigeminal ganglion Top expressed in triceps brachii muscle ankle vastus lateralis muscle sternocleidomastoid muscle temporal muscle knee joint digastric muscle extraocular muscle medial head of gastrocnemius muscle muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function sodium channel regulator activity transmembrane transporter binding sodium channel activity voltage-gated ion channel activity voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity Cellular component voltage-gated sodium channel complex integral component of membrane membrane intercalated disc intrinsic component of plasma membrane plasma membrane Biological process cardiac muscle contraction sodium ion transmembrane transport sodium ion transport regulation of ion transmembrane transport cardiac muscle cell action potential involved in contraction ion transport regulation of sodium ion transmembrane transporter activity positive regulation of sodium ion transport AV node cell action potential regulation of heart rate by cardiac conduction membrane depolarization during cardiac muscle cell action potential regulation of ventricular cardiac muscle cell membrane repolarization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6330 399548 Ensembl ENSG00000177098 ENSMUSG00000046480 UniProt Q8IWT1 Q7M729 RefSeq (mRNA) NM_001142348 NM_001142349 NM_174934 NM_001013390 RefSeq (protein) NP_001135820 NP_001135821 NP_777594 NP_001013408 Location (UCSC) Chr 11: 118.13 – 118.15 Mb Chr 9: 45.05 – 45.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SCN4B might additionally function as a cell adhesion molecule.^[8][9]

See also

• Sodium channel

References

1. GRCh38: Ensembl release 89: ENSG00000177098 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046480 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
6. "Entrez Gene: sodium channel".
7. Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
8. Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.
9. Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

• Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre. 37 (6): 449–56. PMID 1293796.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–85. doi:10.1523/JNEUROSCI.23-20-07577.2003. PMC 6740763. PMID 12930796.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit". Pflügers Arch. 457 (6): 1253–63. doi:10.1007/s00424-008-0600-8. PMC 6207185. PMID 18941776.
• Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8IWT1 (Human Sodium channel subunit beta-4 (SCN4B)) at the PDBe-KB.