Scavenger receptor class B type 1 (SRB1) also known as SR-BI is a protein that in humans is encoded by the SCARB1 gene.[5] SR-BI functions as a receptor for high-density lipoprotein.[6]
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Scavenger receptor class B, type I (SR-BI) is an integral membrane protein found in numerous cell types/tissues, including enterocytes, the liver and adrenal gland. It is best known for its role in facilitating the uptake of cholesteryl esters from high-density lipoproteins in the liver. This process drives the movement of cholesterol from peripheral tissues towards the liver, where cholesterol can either be secreted via the bile duct or be used to synthesise steroid hormones.[7] This movement of cholesterol is known as reverse cholesterol transport and is a protective mechanism against the development of atherosclerosis, which is the principal cause of heart disease and stroke.
SR-BI is crucial in carotenoid and vitamin E uptake in the small intestine.[8][9] SR-B1 is upregulated in times of vitamin A deficiency and downregulated if vitamin A status is in the normal range.[10]
In melanocytic cells SCARB1 gene expression may be regulated by the MITF.[11]
SR-BI has also been identified in the livers of non-mammalian species (turtle, goldfish, shark, chicken, frog, and skate), suggesting it emerged early in vertebrate evolutionary history. The turtle also seems to upregulate SR-BI during egg development, indicating that cholesterol efflux may be at peak levels during developmental stages.[12]
SCARB1 along with CD81 is the receptor for the entry of the Hepatitis C virus into liver cells.[13]
Although malignant tumors are known to display extreme heterogeneity, overexpression of SR-B1 is a relatively consistent marker in cancerous tissues. While SR-B1 normally mediates the transfer of cholesterol between high-density lipoproteins (HDL) and healthy cells, it also facilitates the selective uptake of cholesterol by malignant cells. In this way, upregulation of the SR-B1 receptor becomes an enabling factor for self-sufficient proliferation in cancerous tissue.[14][15]
SR-B1 mediated delivery has also been used in the transfection of cancer cells with siRNA, or small interfering RNAs. This therapy causes RNA interference, in which short segments of double stranded RNA acts to silence targeted oncogenes post-transcription. SR-B1 mediation reduces siRNA degradation and off-target accumulation while enhancing delivery to targeted tissues. In "metastatic and taxane-resistant models of ovarian cancer, rHDL-mediated siren delivery improved responses.[16]
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
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- Husemann J, Silverstein SC (March 2001). "Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain". The American Journal of Pathology. 158 (3): 825–32. doi:10.1016/S0002-9440(10)64030-8. PMC 1850374. PMID 11238031.
- Li XA, Titlow WB, Jackson BA, Giltiay N, Nikolova-Karakashian M, Uittenbogaard A, Smart EJ (March 2002). "High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner". The Journal of Biological Chemistry. 277 (13): 11058–63. doi:10.1074/jbc.M110985200. PMID 11792700.
- Duncan KG, Bailey KR, Kane JP, Schwartz DM (April 2002). "Human retinal pigment epithelial cells express scavenger receptors BI and BII". Biochemical and Biophysical Research Communications. 292 (4): 1017–22. doi:10.1006/bbrc.2002.6756. PMID 11944916.
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