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From Wikipedia, the free encyclopedia
RsaOG (an acronym for RNA S. aureus Orsay G)[2] is a non-coding RNA that was discovered in the pathogenic bacteria Staphylococcus aureus N315 using a large scale computational screening based on phylogenetic profiling.[3] It was first identified, but not named, in 2005.[4] RsaOG has since been identified in other strains of Staphylococcus aureus under the name of RsaI,[5] it has also been discovered in other members of the Staphylococcus genus (such as Staphylococcus carnosus) but in no other bacteria.[2]
| rsaOG RNA | |
|---|---|
 The consensus secondary structure of RsaOG showing its pseudoknot, created in Varna.[1] Boundaries were determined by RACE mapping in Staphylococcus aureus N315.[2] | |
| Identifiers | |
| Symbol | RsaOG |
| Rfam | RF01775 |
| Other data | |
| RNA type | sRNA |
| Domain(s) | Staphylococcus |
| PDB structures | PDBe |
The RsaOG gene is conserved in all Staphylococcaceae sequenced genomes, its secondary structure contains two highly conserved unpaired sequences which have the ability to form a pseudoknot.[2] Northern blot experiments show that RsaOG is expressed in several S. aureus strains.[3][5] Mapping of RsaOG ends indicates a size of 146 nucleotides in S. aureus.[5] RsaOG ncRNA is thought to have trans-acting regulatory functions, possibly on fine tuning toxin production or aiding with invasion.[2]
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