Medical condition From Wikipedia, the free encyclopedia
Restrictive dermopathy (RD) is a rare, lethal autosomal recessive skin condition characterized by syndromic facies, tight skin, sparse or absent eyelashes, and secondary joint changes.[2]: 563
Restrictive dermopathy | |
---|---|
Other names | Hyperkeratosis-contracture syndrome, Lethal restrictive dermopathy |
![]() | |
Restrictive dermopathy is inherited in an autosomal recessive manner[1] | |
Specialty | Medical genetics |
Restrictive dermopathy (RD) is caused either by the loss of the gene ZMPSTE24, which encodes a protein responsible for the cleavage of farnesylated prelamin A into mature non-farnesylated lamin, or by a mutation in the LMNA gene. This results in the accumulation of farnesyl-prelamin A at the nuclear membrane.[3] Mechanistically, restrictive dermopathy is somewhat similar to Hutchinson–Gilford progeria syndrome (HGPS), a disease where the last step in lamin processing is hindered by a mutation that causes the loss of the ZMPSTE24 cleavage site in the lamin A gene.[citation needed]
![]() | This section is empty. You can help by adding to it. (August 2017) |
![]() | This section is empty. You can help by adding to it. (August 2017) |
Seamless Wikipedia browsing. On steroids.