Renanolone

Renanolone
Clinical data
ATC code	none;
Identifiers
	IUPAC name 3α-hydroxy-5β-pregnane-11,20-dione;
CAS Number	565-99-1;
PubChem CID	68930;
ChemSpider	16736755;
UNII	D8Z6E4IR2J;
CompTox Dashboard (EPA)	DTXSID101024028 ;
Chemical and physical data
Formula	C20H30O4
Molar mass	334.456 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(O)[C@H]3C(=O)C[C@]12C;
	InChI InChI=1S/C20H30O4/c1-11(21)15-5-6-16-14-4-3-12-9-13(22)7-8-20(12,24)18(14)17(23)10-19(15,16)2/h12-16,18,22,24H,3-10H2,1-2H3/t12-,13-,14+,15-,16+,18-,19-,20-/m1/s1; Key:ICICFVFEPDWWAQ-MNYWXNLXSA-N;

Renanolone (INN), or 11-ketopregnanolone, also known as 5β-pregnan-3α-ol-11,20-dione, is a synthetic^{[citation needed]} neuroactive steroid which is described as a general anesthetic but was never introduced for clinical use.^[1] Its isomers, alfaxolone and alfadolone, are also general anesthetics, and are known to act as positive allosteric modulators of the GABA_A receptor, a property which is likely the case for renanolone as well.

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[1]
Hill RA, Makin HL, Kirk DN, Murphy GM (23 May 1991). Dictionary of Steroids. CRC Press. p. 592. ISBN 978-0-412-27060-4.

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Chemistry

Clinical data

ATC code	none
Identifiers
IUPAC name 3α-hydroxy-5β-pregnane-11,20-dione
CAS Number	565-99-1
PubChem CID	68930
ChemSpider	16736755
UNII	D8Z6E4IR2J
CompTox Dashboard (EPA)	DTXSID101024028
Chemical and physical data
Formula	C₂₀H₃₀O₄
Molar mass	334.456 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(O)[C@H]3C(=O)C[C@]12C
InChI InChI=1S/C20H30O4/c1-11(21)15-5-6-16-14-4-3-12-9-13(22)7-8-20(12,24)18(14)17(23)10-19(15,16)2/h12-16,18,22,24H,3-10H2,1-2H3/t12-,13-,14+,15-,16+,18-,19-,20-/m1/s1 Key:ICICFVFEPDWWAQ-MNYWXNLXSA-N