Renanolone

Renanolone (INN), or 11-ketopregnanolone, also known as 5β-pregnan-3α-ol-11,20-dione, is a synthetic^{[citation needed]} neuroactive steroid which is described as a general anesthetic but was never introduced for clinical use.^[1] Its isomers, alfaxolone and alfadolone, are also general anesthetics, and are known to act as positive allosteric modulators of the GABA_A receptor, a property which is likely the case for renanolone as well.

Renanolone

Clinical data
ATC code	none
Identifiers
IUPAC name 3α-hydroxy-5β-pregnane-11,20-dione
CAS Number	565-99-1
PubChem CID	68930
ChemSpider	16736755
UNII	D8Z6E4IR2J
CompTox Dashboard (EPA)	DTXSID101024028
Chemical and physical data
Formula	C20H30O4
Molar mass	334.456 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(O)[C@H]3C(=O)C[C@]12C
InChI InChI=1S/C20H30O4/c1-11(21)15-5-6-16-14-4-3-12-9-13(22)7-8-20(12,24)18(14)17(23)10-19(15,16)2/h12-16,18,22,24H,3-10H2,1-2H3/t12-,13-,14+,15-,16+,18-,19-,20-/m1/s1 Key:ICICFVFEPDWWAQ-MNYWXNLXSA-N

Chemistry

See also: List of neurosteroids

See also

• Alfadolone
• Alfaxolone
• Ganaxolone
• Hydroxydione
• Minaxolone
• Pregnanolone