RU-56187

RU-56187
Clinical data
Drug class	Nonsteroidal antiandrogen
Identifiers
	IUPAC name 2-(Trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl)benzonitrile;
CAS Number	143782-25-6;
PubChem CID	132581;
ChemSpider	117054;
UNII	L6RT6E57LS;
ChEMBL	ChEMBL1099140;
CompTox Dashboard (EPA)	DTXSID90162545 ;
Chemical and physical data
Formula	C14H12F3N3OS
Molar mass	327.33 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(C(=O)N(C(=S)N1C)C2=CC(=C(C=C2)C#N)C(F)(F)F)C;
	InChI InChI=1S/C14H12F3N3OS/c1-13(2)11(21)20(12(22)19(13)3)9-5-4-8(7-18)10(6-9)14(15,16)17/h4-6H,1-3H3; Key:HLBUAKQNKJTEIU-UHFFFAOYSA-N;

RU-56187 is a nonsteroidal antiandrogen which was never marketed.^[1]^[2]^[3]^[4]^[5] It shows 92% of the affinity of testosterone for the androgen receptor and negligible affinity for other steroid hormone receptors.^[1]^[2] The medication is a silent antagonist of the androgen receptor.^[5] RU-56187 is 3- to 10-fold more potent as an antiandrogen than bicalutamide or nilutamide in animals.^[1] Both RU-56187 and RU-58841 appear to be prodrugs of cyanonilutamide (RU-56279) in vivo in animals.^[3]

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